Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25869512 | 0.87 | ALDH1A1 (0.41) | CYP1A2ALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL27729422 | 0.81 | SIRT2 (0.44) | ALDH1A1KDM4EKIF11NPC1MAPT | |
| SCHEMBL4214065 | 0.81 | SIRT2 (0.44) | ALDH1A1KDM4EKIF11NPC1MAPT | |
| SCHEMBL7205029 | 0.81 | SLC7A5 (0.56) | CYP1A2HSD17B10SLC7A5ALDH1A1KDM4E | |
| SCHEMBL5283089 | 0.81 | SLC7A5 (0.56) | CYP1A2HSD17B10SLC7A5ALDH1A1KDM4E | |
| SCHEMBL15360000 | 0.81 | CYP1A2 (0.49) | CYP1A2HSD17B10SLC7A5ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL4219539 | 0.80 | SIRT2 (0.43) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL27729421 | 0.80 | SIRT2 (0.43) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL20422675 | 0.80 | SLC7A5 (0.54) | CYP1A2HSD17B10SLC7A5ALDH1A1KDM4E | |
| SCHEMBL12128833 | 0.80 | CYP1A2 (0.47) | CYP1A2HSD17B10SLC7A5PTGS1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111828-A1 | L-ALANINE DERIVATIVES | ASTRAZENECA AB | 2009-04-30 | — | — | US | disclosed |
| EP-1957476-A1 | L-ALANINE DERIVATIVES | AstraZeneca AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007060409-A1 | L-ALANINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111828-A1 | L-ALANINE DERIVATIVES | ITGA2B, ITGB1, ITGB5 | CYP1A2 4447/4885HSD17B10 2676/4885SLC7A5 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.