Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 9/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3535964 | 0.81 | DEGS1 (0.50) | HCAR3 | |
| SCHEMBL29203312 | 0.81 | RAB9A (0.56) | HCAR3TP53MEN1KMT2AMAPT | |
| SCHEMBL3535967 | 0.81 | DEGS1 (0.50) | HCAR3 | |
| SCHEMBL17911708 | 0.80 | FDPS (0.51) | FDPSTSHRHCAR3TP53MEN1 | |
| SCHEMBL1181647 | 0.78 | FDPS (0.56) | FDPSTSHRHCAR3TP53MEN1 | |
| SCHEMBL16554276 | 0.78 | HCAR3 (0.46) | FDPSHCAR3MAPTRAB9AMAPK1 | |
| SCHEMBL16554275 | 0.78 | HCAR3 (0.46) | FDPSHCAR3MAPTRAB9AMAPK1 | |
| SCHEMBL17925373 | 0.76 | HCAR3 (0.45) | FDPSHCAR3TP53RAB9ANPC1 | |
| SCHEMBL15163940 | 0.75 | FDPS (0.71) | FDPSTSHRHCAR3TP53MEN1 | |
| SCHEMBL9769258 | 0.75 | RAB9A (0.55) | TSHRTP53MEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111828-A1 | L-ALANINE DERIVATIVES | ASTRAZENECA AB | 2009-04-30 | — | — | US | disclosed |
| EP-1957476-A1 | L-ALANINE DERIVATIVES | AstraZeneca AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007060409-A1 | L-ALANINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111828-A1 | L-ALANINE DERIVATIVES | ITGA2B, ITGB1, ITGB5 | FDPS 3823/4885TSHR 4452/4885HCAR3 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.