Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 8/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 2/20 | 0.33 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16554276 | 1.00 | HCAR3 (0.46) | HCAR3HCAR2DGAT1MAPTRAB9A | |
| SCHEMBL3535967 | 0.79 | DEGS1 (0.50) | HCAR3HCAR2DEGS1 | |
| SCHEMBL29203312 | 0.79 | RAB9A (0.56) | HCAR3HCAR2MAPTRAB9AALDH1A1 | |
| SCHEMBL3535964 | 0.79 | DEGS1 (0.50) | HCAR3HCAR2DEGS1 | |
| SCHEMBL4208146 | 0.78 | FDPS (0.55) | HCAR3MAPTRAB9AALDH1A1FDPS | |
| SCHEMBL16553828 | 0.77 | KDM4C (0.40) | HCAR3ALDH1A1SCN9AKDM4CFDPS | |
| SCHEMBL16553830 | 0.77 | KDM4C (0.40) | HCAR3ALDH1A1SCN9AKDM4CFDPS | |
| SCHEMBL17925373 | 0.74 | HCAR3 (0.45) | HCAR3HCAR2DGAT1RAB9AALDH1A1 | |
| SCHEMBL44234 | 0.70 | POLB (0.55) | RAB9AALDH1A1FDPS | |
| SCHEMBL503092 | 0.70 | POLB (0.55) | RAB9AALDH1A1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10053476-B2 | Phosphohistidine and phosphotyrosine analogues | UNIVERSITY OF SHEFFIELD (GB) | 2018-08-21 | — | — | US | disclosed |
| EP-2976346-B1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIV SHEFFIELD (GB) | 2017-02-22 | — | — | EP | disclosed |
| US-20160207948-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIVERSITY OF SHEFFIELD (GB) | 2016-07-21 | — | — | US | disclosed |
| EP-2976346-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | University of Sheffield (GB) | 2016-01-27 | — | — | EP | disclosed |
| WO-2015033120-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIVERSITY OF SHEFFIELD (GB) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207948-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | HRH3, CYTH3, CYTH2 | HCAR3 1347/4885HCAR2 1612/4885DGAT1 4809/4885 |
| US-10053476-B2 | Phosphohistidine and phosphotyrosine analogues | HRH3, CYTH3, CYTH2 | HCAR3 1360/4885HCAR2 1623/4885DGAT1 4818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.