Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | KCNA1 | Q09470 | 2/20 | 0.34 |
| ▸ | KCNAB1 | Q14722 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28974312 | 0.90 | NOTUM (0.39) | NOTUMHDAC6ESR2HDAC8NR1H2 | |
| SCHEMBL13568080 | 0.83 | ESR2 (0.51) | ESR2NR1H2GRM5MAPTMEN1 | |
| SCHEMBL28935862 | 0.80 | SORT1 (0.39) | HDAC6ESR2HDAC8GRM5MAPT | |
| SCHEMBL18806154 | 0.80 | NOTUM (0.41) | NOTUMHDAC6ESR2HDAC8NR1H2 | |
| SCHEMBL3722961 | 0.79 | ABHD6 (0.39) | NOTUMHDAC6KCNA1KCNAB1HDAC8 | |
| SCHEMBL4011215 | 0.78 | GRM5 (0.36) | NOTUMESR2GRM5ENPP2MAPT | |
| SCHEMBL18806197 | 0.78 | GABRG2 (0.48) | NOTUMNR1H2GRM5ENPP2MAPT | |
| SCHEMBL18819906 | 0.78 | CDK6 (0.40) | NOTUMENPP2GABRG2GABRB3GABRA5 | |
| SCHEMBL20249388 | 0.78 | PDGFRB (0.39) | NOTUMHDAC6KCNA1KCNAB1HDAC8 | |
| SCHEMBL28935833 | 0.77 | GRM5 (0.37) | NOTUMNR1H2GRM5MAPTGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312306-A1 | TETRAHYDRO-5H-PYRIDO[2,3-D]AZEPINES AS 5-HT2C LIGANDS | CASCADE THERAPEUTICS INC. (CA) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312306-A1 | TETRAHYDRO-5H-PYRIDO[2,3-D]AZEPINES AS 5-HT2C LIGANDS | HTR2C, HTR2A, HTR5A | NOTUM 4402/4885HDAC6 2249/4885ESR2 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.