SCHEMBL4209759

SCHEMBL4209759

O=C(O)[C@@H]1C[C@@H]1c1ccc(F)cc1

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC9A1 P19634 1/20 0.60
FFAR1 O14842 6/20 0.59
HRH3 Q9Y5N1 2/20 0.51
KDM1A O60341 2/20 0.50
SIGMAR1 Q99720 2/20 0.49
MAPT P10636 3/20 0.46
HDAC4 P56524 1/20 0.46
GAA P10253 1/20 0.46
HPGD P15428 1/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPK1 P28482 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1839154 1.00 SLC9A1 (0.60) SLC9A1FFAR1HRH3KDM1ASIGMAR1
SCHEMBL11902437 1.00 SLC9A1 (0.60) SLC9A1FFAR1HRH3KDM1ASIGMAR1
SCHEMBL14550059 1.00 SLC9A1 (0.60) SLC9A1FFAR1HRH3KDM1ASIGMAR1
SCHEMBL1839151 1.00 SLC9A1 (0.60) SLC9A1FFAR1HRH3KDM1ASIGMAR1
SCHEMBL1019425 1.00 SLC9A1 (0.60) SLC9A1FFAR1HRH3KDM1ASIGMAR1
SCHEMBL34467094 0.87 MAPT (0.53) SLC9A1FFAR1MAPTGAAHPGD
SCHEMBL16232154 0.84 SLC9A1 (0.60) SLC9A1HRH3KDM1ASIGMAR1MAPT
SCHEMBL17189659 0.84 SLC9A1 (0.65) SLC9A1FFAR1HRH3KDM1ASIGMAR1
SCHEMBL13976000 0.84 SLC9A1 (0.65) SLC9A1FFAR1HRH3KDM1ASIGMAR1
SCHEMBL12765396 0.84 SLC9A1 (0.60) SLC9A1HRH3KDM1ASIGMAR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4559902-A2 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE Imago Biosciences Inc. (US) 2025-05-28 EP disclosed
EP-3256218-B1 A KDM1A INHIBITOR AND ITS USE IN THERAPY IMAGO BIOSCIENCES INC (US) 2024-12-11 EP disclosed
US-11773068-B2 KDM1A inhibitors for the treatment of disease IMAGO BIOSCIENCES, INC. (US) 2023-10-03 US disclosed
US-20220073477-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. 2022-03-10 US disclosed
CN-112312902-B Pd (II) -catalyzed enantioselective C-H arylation of free carboxylic acids 斯克里普斯研究学院 2022-02-18 CN disclosed
US-11230534-B2 KDM1A inhibitors for the treatment of disease IMAGO BIOSCIENCES, INC. (US) 2022-01-25 US disclosed
CN-107427699-B KDM1A inhibitors for the treatment of disease 伊美格生物科学公司 2021-10-19 CN disclosed
US-11021427-B2 Pd(II)-catalyzed enantioselective C—H arylation of free carboxylic acids THE SCRIPPS RESEARCH INSTITUTE (US) 2021-06-01 US disclosed
US-11021427-B2 Pd(II)-catalyzed enantioselective C—H arylation of free carboxylic acids THE SCRIPPS RESEARCH INSTITUTE (US) 2021-06-01 US disclosed
US-20210087131-A1 PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS THE SCRIPPS RESEARCH INSTITUTE 2021-03-25 US disclosed
US-20210087131-A1 PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS THE SCRIPPS RESEARCH INSTITUTE 2021-03-25 US disclosed
US-20200283397-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. 2020-09-10 US disclosed
WO-2019204477-A1 PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS THE SCRIPPS RESEARCH INSTITUTE (US) 2019-10-24 WO disclosed
US-20180312474-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. 2018-11-01 US disclosed
US-9981922-B2 KDM1A inhibitors for the treatment of disease IMAGO BIOSCIENCES, INC. (US) 2018-05-29 US disclosed
WO-2017165822-A1 SMALL MOLECULE INHIBITOR OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2017-09-28 WO disclosed
US-20160237043-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. 2016-08-18 US disclosed
US-20090036473-A1 NOVEL QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE NEUROSEARCH A/S (DK) 2009-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090036473-A1 NOVEL QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE KCNK17, KCNN3, KCNA7 SLC9A1 263/4885FFAR1 2816/4885HRH3 1085/4885
US-20200283397-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1B, KDM1A, KDM2A SLC9A1 3240/4885FFAR1 4334/4885HRH3 1345/4885
US-11230534-B2 KDM1A inhibitors for the treatment of disease KDM1B, KDM1A, KDM2A SLC9A1 3240/4885FFAR1 4334/4885HRH3 1345/4885
US-20180312474-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1B, KDM1A, KDM2A SLC9A1 3240/4885FFAR1 4334/4885HRH3 1345/4885
US-20160237043-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1B, KDM1A, KDM2A SLC9A1 3240/4885FFAR1 4334/4885HRH3 1345/4885
US-20220073477-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1B, KDM1A, KDM2A SLC9A1 3240/4885FFAR1 4334/4885HRH3 1345/4885
US-11021427-B2 Pd(II)-catalyzed enantioselective C—H arylation of free carboxylic acids PDCD1, PDK3, PDCD1LG2 SLC9A1 2367/4885FFAR1 119/4885HRH3 49/4885
US-11773068-B2 KDM1A inhibitors for the treatment of disease KDM1B, KDM1A, KDM2A SLC9A1 3240/4885FFAR1 4334/4885HRH3 1345/4885
US-20210087131-A1 PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS PDCD1, PDK3, PDCD1LG2 SLC9A1 2369/4885FFAR1 124/4885HRH3 38/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.