Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857282 | 0.80 | ALOX5 (0.51) | RAB9AGAAMAPTALDH1A1HPGD | |
| SCHEMBL4216357 | 0.80 | ALDH1A1 (0.54) | KMT2ARAB9AGAATDP1SLC6A2 | |
| SCHEMBL4216365 | 0.80 | ALDH1A1 (0.54) | KMT2ARAB9AGAATDP1SLC6A2 | |
| SCHEMBL20830910 | 0.77 | TSHR (0.65) | KMT2ARAB9AGAATDP1SLC6A2 | |
| SCHEMBL13481158 | 0.77 | KMT2A (0.63) | KMT2ARAB9AGAATDP1SLC6A2 | |
| SCHEMBL312287 | 0.77 | KMT2A (0.92) | KMT2ARAB9AGAATDP1SLC6A2 | |
| SCHEMBL20830918 | 0.76 | KMT2A (0.67) | KMT2ARAB9AGAATDP1SLC6A2 | |
| SCHEMBL11416620 | 0.76 | TSHR (0.78) | KMT2ARAB9AGAATDP1SLC6A2 | |
| SCHEMBL2704247 | 0.76 | KMT2A (0.71) | KMT2ARAB9AGAATDP1SLC6A2 | |
| Benzyl Benzoate SCHEMBL9058384 | 0.76 | TDP1 (0.82) | KMT2ARAB9AGAATDP1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054629-A1 | Inhibitors of Transthyretin Amyloid Fibril Formation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-02-26 | — | — | US | disclosed |
| US-7312361-B2 | Inhibitors of transthyretin amyloid fibril formation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-12-25 | — | — | US | disclosed |
| US-20060178527-A1 | Inhibitors of transthyretin amyloid fibril formation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054629-A1 | Inhibitors of Transthyretin Amyloid Fibril Formation | TTR, TTPA, APOB | KMT2A 3558/4885RAB9A 3490/4885GAA 1261/4885 |
| US-20060178527-A1 | Inhibitors of transthyretin amyloid fibril formation | TTR, TTPA, APOB | KMT2A 3558/4885RAB9A 3490/4885GAA 1261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.