Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | CFTR | P13569 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4310578 | 0.84 | RAB9A (0.49) | RAB9AALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL31276114 | 0.74 | MAPT (0.62) | RAB9AALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL5947079 | 0.73 | HTR2A (0.53) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL24893277 | 0.72 | HTR2A (0.52) | RAB9AALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL4215072 | 0.72 | CFTR (0.49) | RAB9ACFTRALDH1A1NPC1MAPT | |
| SCHEMBL6163228 | 0.72 | MET (0.40) | RAB9ACFTRALDH1A1NPC1MAPT | |
| SCHEMBL6738366 | 0.68 | TSHR (0.76) | RAB9AALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL5946668 | 0.68 | CYP19A1 (0.46) | RAB9AALDH1A1MAPTTSHR | |
| SCHEMBL28920240 | 0.68 | RAB9A (0.44) | RAB9AALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL6730727 | 0.68 | CFTR (0.47) | RAB9ACFTRALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018156-A1 | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018156-A1 | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors | BRAF, RAF1, ARAF | RAB9A 882/4885CFTR 3632/4885ALDH1A1 3294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.