Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4206760 | 0.94 | MAPT (0.47) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL4212296 | 0.92 | MAPT (0.44) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL4210858 | 0.87 | CASR (0.42) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL4217249 | 0.83 | MAPT (0.52) | MAPTRAB9ANPC1ALDH1A1HDAC3 | |
| SCHEMBL4213903 | 0.83 | RAB9A (0.41) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL2437797 | 0.81 | CASR (0.63) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL4534260 | 0.78 | RORC (0.44) | MAPTRAB9AALDH1A1KDM4EPHGDH | |
| SCHEMBL4224637 | 0.78 | CASR (0.44) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL4221174 | 0.76 | CASR (0.42) | MAPTRAB9ANPC1ALDH1A1CASR | |
| SCHEMBL4536241 | 0.75 | MAPT (0.49) | MAPTRAB9ANPC1PARP1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041103-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | Galapagos SAS (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008006625-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | GALAPAGOS SAS (FR) | 2008-01-17 | — | — | WO | disclosed |