Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4217249 | 0.85 | MAPT (0.52) | MAPTROCK2ROCK1ELOVL1PARP1 | |
| SCHEMBL2437673 | 0.77 | CASR (0.63) | MAPTROCK2ROCK1MEN1STAT3 | |
| SCHEMBL4206760 | 0.76 | MAPT (0.47) | MAPTROCK2ROCK1PARP1NPC1 | |
| SCHEMBL4212296 | 0.75 | MAPT (0.44) | MAPTROCK2ROCK1PARP1NPC1 | |
| SCHEMBL4218293 | 0.75 | MAPT (0.46) | MAPTROCK2ROCK1PARP1NPC1 | |
| SCHEMBL4534260 | 0.75 | RORC (0.44) | MAPTROCK2ROCK1MEN1KMT2A | |
| SCHEMBL4210858 | 0.72 | CASR (0.42) | MAPTROCK2ROCK1PARP1NPC1 | |
| SCHEMBL4220282 | 0.72 | LMNA (0.45) | MAPTMEN1KMT2AELOVL1PARP1 | |
| SCHEMBL4213903 | 0.72 | RAB9A (0.41) | MAPTROCK2ROCK1KMT2APARP1 | |
| SCHEMBL4746922 | 0.71 | CASR (0.56) | MAPTMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041103-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | Galapagos SAS (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008006625-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | GALAPAGOS SAS (FR) | 2008-01-17 | — | — | WO | disclosed |