Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PHGDH | O43175 | 4/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4217249 | 0.86 | MAPT (0.52) | RAB9ALMNAMAPTALDH1A1ROCK2 | |
| SCHEMBL2433184 | 0.80 | CASR (0.58) | RORCKDM4ERAB9AMAPK1LMNA | |
| SCHEMBL4206760 | 0.79 | MAPT (0.47) | KDM4ERAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL4212296 | 0.78 | MAPT (0.44) | KDM4ERAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL4218293 | 0.78 | MAPT (0.46) | KDM4ERAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL2433485 | 0.77 | CASR (0.60) | RORCKDM4ERAB9AMAPK1MAPT | |
| SCHEMBL4210858 | 0.75 | CASR (0.42) | KDM4ERAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL4213903 | 0.75 | RAB9A (0.41) | KDM4ERAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL4536241 | 0.75 | MAPT (0.49) | RAB9AMAPTMEN1KMT2AROCK2 | |
| SCHEMBL4220282 | 0.74 | LMNA (0.45) | RAB9AMAPK1LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041103-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | Galapagos SAS (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008006625-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | GALAPAGOS SAS (FR) | 2008-01-17 | — | — | WO | disclosed |