Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 8/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4216209 | 0.98 | GRIN1 (0.45) | GRIN1GRIN2BSIGMAR1HTR7HTR6 | |
| SCHEMBL8982042 | 0.91 | HTR7 (0.45) | GRIN1GRIN2BSIGMAR1HTR7HTR6 | |
| SCHEMBL14502634 | 0.91 | HTR7 (0.44) | GRIN1GRIN2BSIGMAR1HTR7HTR6 | |
| SCHEMBL4222498 | 0.87 | GRIN1 (0.47) | GRIN1GRIN2BSIGMAR1HTR7HTR6 | |
| SCHEMBL8981888 | 0.85 | HTR7 (0.62) | HTR7HTR6DRD2 | |
| SCHEMBL4228663 | 0.85 | GRIN1 (0.49) | GRIN1GRIN2BSIGMAR1HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL4224360 | 0.85 | HTR7 (0.61) | HTR7HTR6DRD2 | |
| Hydrochloric Acid SCHEMBL4224217 | 0.83 | GRIN1 (0.47) | GRIN1GRIN2BSIGMAR1HTR7HTR6 | |
| SCHEMBL4218203 | 0.83 | HTR7 (0.56) | GRIN1GRIN2BSIGMAR1HTR7HTR6 | |
| SCHEMBL4231325 | 0.83 | SIGMAR1 (0.53) | GRIN1GRIN2BSIGMAR1HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| WO-2009028899-A1 | 1'-ALKYLPIPERIDINE-4'-SPIRO-2-6-(AMIDO)-2H-BENZOPYRAN DERIVATIVES HAVING ANTICANCER ACTIVITY | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2009-03-05 | — | — | WO | disclosed |
| US-7211585-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-01 | — | — | US | disclosed |
| US-20060040978-A1 | 5-HT7 receptor antagonists | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163542-A1 | 5-ht7 receptor antagonists | HTR7, HTR1A, HTR5A | GRIN1 220/4885GRIN2B 80/4885SIGMAR1 140/4885 |
| US-20060040978-A1 | 5-HT7 receptor antagonists | HTR7, HTR1A, HTR5A | GRIN1 220/4885GRIN2B 80/4885SIGMAR1 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.