Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11663201 | 0.83 | AKR1B1 (0.61) | MAPK14MAOANPC1RAB9AKMT2A | |
| SCHEMBL7833676 | 0.82 | MAPK14 (0.52) | MAPK14KMT2AMEN1AKR1B1CYP1A2 | |
| SCHEMBL5763727 | 0.80 | MAOA (0.44) | MAPK14MAOANPC1RAB9AKMT2A | |
| SCHEMBL7820594 | 0.80 | NPC1 (0.86) | MAPK14MAOANPC1RAB9AKMT2A | |
| SCHEMBL2007673 | 0.77 | AKR1B1 (0.57) | MAPK14ALDH1A1SMN1; SMN2AKR1B1POLB | |
| SCHEMBL8880119 | 0.76 | AKR1B1 (0.66) | MAPK14KMT2AMAPTMEN1AKR1B1 | |
| SCHEMBL2812760 | 0.76 | MAOA (1.00) | MAOANPC1RAB9AKMT2AMAPT | |
| SCHEMBL4224574 | 0.75 | MAPK14 (0.65) | MAPK14MAOANPC1RAB9AKMT2A | |
| SCHEMBL4224487 | 0.75 | MAPK14 (1.00) | MAPK14AKR1B1 | |
| SCHEMBL11569877 | 0.75 | AKR1B1 (0.61) | MAPK14MAOANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105327-A1 | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds | MERCKLE GMBH (DE) | 2009-04-23 | — | — | US | claimed |
| EP-1881968-A2 | DIBENZOCYCLOHEPTANE COMPOUNDS AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS | MERCKLE GMBH (DE) | 2008-01-30 | — | — | EP | claimed |
| WO-2006120010-A2 | DIBENZOCYCLOHEPTANE COMPOUNDS AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS | MERCKLE GMBH (DE) | 2006-11-16 | — | — | WO | claimed |
| US-20090105327-A1 | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds | MERCKLE GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105327-A1 | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds | MERCKLE GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
| EP-1881968-A2 | DIBENZOCYCLOHEPTANE COMPOUNDS AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS | MERCKLE GMBH (DE) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006120010-A2 | DIBENZOCYCLOHEPTANE COMPOUNDS AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS | MERCKLE GMBH (DE) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105327-A1 | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds | BDKRB1, IL1R1, IL1A | MAPK14 3479/4885MAOA 1574/4885NPC1 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.