Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.58 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842016 | 0.78 | PARP1 (0.61) | PARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6841345 | 0.75 | PARP1 (0.64) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL7319077 | 0.74 | PARP1 (1.00) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL6842031 | 0.73 | PARP1 (0.66) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL27824103 | 0.72 | PARP1 (0.60) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL6406539 | 0.72 | LMNA (0.61) | — | |
| SCHEMBL8620143 | 0.71 | PARP1 (0.65) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL6841346 | 0.71 | PARP1 (0.61) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL6836770 | 0.69 | RAB9A (0.59) | PARP1PLA2G2AALOX15PTGS2PKN1 | |
| SCHEMBL6842032 | 0.68 | PARP1 (0.60) | PARP1PLA2G2AALOX15PTGS2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022026-A1 | METHOD OF TREATING CANCER | ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) | 2012-01-26 | — | — | US | claimed |
| EP-2387403-A1 | METHOD OF TREATING CANCER | Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) | 2011-11-23 | — | — | EP | claimed |
| US-20110253692-A1 | Electrical heater for vehicle windshields and windows | SCHAUBLE RICHARD EGON | 2011-10-20 | — | — | US | claimed |
| WO-2010082821-A1 | METHOD OF TREATING CANCER | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2010-07-22 | — | — | WO | claimed |
| US-20120022026-A1 | METHOD OF TREATING CANCER | ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) | 2012-01-26 | — | — | US | disclosed |
| EP-2387403-A1 | METHOD OF TREATING CANCER | Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) | 2011-11-23 | — | — | EP | disclosed |
| US-20110253692-A1 | Electrical heater for vehicle windshields and windows | SCHAUBLE RICHARD EGON | 2011-10-20 | — | — | US | disclosed |
| WO-2010082821-A1 | METHOD OF TREATING CANCER | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2010-07-22 | — | — | WO | disclosed |