SCHEMBL4225014

SCHEMBL4225014

O=C1c2ccc(O)c(O)c2C(=O)N1Cc1ccc(F)cc1F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 3/20 0.43
ACHE P22303 4/20 0.41
AKR1B10 O60218 1/20 0.40
AKR1A1 P14550 1/20 0.40
BRD4 O60885 1/20 0.39
KDM4E B2RXH2 3/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 1/20 0.36
USP2 O75604 1/20 0.36
ALDH1A1 P00352 1/20 0.36
RAF1 P04049 1/20 0.36
TP53 P04637 1/20 0.36
CYP3A4 P08684 1/20 0.36
MAPT P10636 1/20 0.36
THRB P10828 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
CSNK2A2 P19784 1/20 0.36
MAOA P21397 1/20 0.36
APEX1 P27695 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4379360 0.90 GRM5 (0.38) AKR1B1KDM4ESMN1; SMN2MEN1USP2
SCHEMBL13952233 0.87 AKR1B1 (0.42) AKR1B1ACHEAKR1B10AKR1A1BRD4
SCHEMBL4379298 0.86 MEN1 (0.35) AKR1B1KDM4ESMN1; SMN2MEN1USP2
SCHEMBL4371218 0.84 ALDH1A1 (0.45) ACHEKDM4EMEN1ALDH1A1MAPT
SCHEMBL4369470 0.83 P2RX7 (0.35) KDM4ESMN1; SMN2MEN1USP2ALDH1A1
SCHEMBL4224823 0.82 MEN1 (0.36) AKR1B1KDM4EMEN1USP2ALDH1A1
SCHEMBL4374700 0.81 CASP3 (0.52) MEN1USP2ALDH1A1MAPTHPGD
SCHEMBL4367878 0.81 GRM5 (0.43) AKR1B1KDM4ESMN1; SMN2MEN1USP2
SCHEMBL4366780 0.80 CA12 (0.43) KDM4EMEN1USP2ALDH1A1RAF1
SCHEMBL4369764 0.79 UBE2N (0.51) KDM4ESMN1; SMN2MEN1USP2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009026248-A2 HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) 2009-02-26 WO claimed
WO-2009026248-A2 HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) 2009-02-26 WO disclosed