Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 7/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | BDKRB2 | P30411 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5091347 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 | |
| Bromide SCHEMBL5093099 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 | |
| Bromide SCHEMBL197090 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 | |
| Bromide SCHEMBL1517962 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 | |
| Bromide SCHEMBL3216257 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 | |
| Bromide SCHEMBL1023018 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 | |
| Bromide SCHEMBL5086746 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 | |
| Bromide SCHEMBL3112034 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 | |
| Bromide SCHEMBL9574841 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 | |
| Bromide SCHEMBL5086682 | 1.00 | DNM1 (1.00) | DNM1TSHRTHRBBDKRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 279 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116948547-A | Novel white reinforced photovoltaic backboard base film, preparation method and application thereof | 宁波勤邦新材料科技股份有限公司 | 2023-10-27 | — | — | CN | claimed |
| CN-114561034-A | Antimicrobial modified sulfonated styrene-based polymer compound and preparation method thereof | 中国科学院长春应用化学研究所 | 2022-05-31 | — | — | CN | claimed |
| CN-102675707-A | Quaternary phosphonium salt montmorillonoid enhanced polyolefin nanocomposite and preparation method thereof | UNIV HENAN SCIENCE & TECH | 2012-09-19 | — | — | CN | claimed |
| CN-101268055-B | Process for preparing 5-fluoro-1, 3-dialkyl-1H-pyrazole-4-carbonyl fluorides | BAYER CROPSCIENCE AG | 2011-02-16 | — | — | CN | claimed |
| US-7714144-B2 | 5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl chloride are initially charged in polyethylene glycol dimethyl ether, potassium fluoride and tetraphenylphosphonium bromide as phase tranfer catalyst and sulfolane to produce 5-fluoro-1,3-dimethyl-1H-pyrazole-4-carbonyl fluoride | BAYER CROPSCIENCE AG (DE) | 2010-05-11 | — | — | US | claimed |
| US-20090306401-A1 | Method For The Production of 5-Fluoro-1,3-Dialkyl-1H-Pyrazol-4-Carbonyl Fluorides | BAYER CROPSCIENCE AG (DE) | 2009-12-10 | — | — | US | claimed |
| EP-1483333-B1 | THERMOPLASTIC MOULDING MATERIAL AND MOULDED BODIES PRODUCED THEREFROM | TICONA GMBH (DE) | 2008-12-31 | — | — | EP | claimed |
| EP-1928839-B1 | METHOD FOR THE PRODUCTION OF 5-FLUORO-1,3-DIALKYL-1H-PYRAZOL-4-CARBONYL FLUORIDES | BAYER CROPSCIENCE AG (DE) | 2008-12-31 | — | — | EP | claimed |
| CN-101268055-A | Process for preparing 5-fluoro-1, 3-dialkyl-1H-pyrazole-4-carbonyl fluorides | BAYER CROPSCIENCE AG (DE) | 2008-09-17 | — | — | CN | claimed |
| EP-1483330-B1 | POLYOXYMETHYLENE MOLDING COMPOUND AND MOLDED BODY PRODUCED THEREFROM | TICONA GMBH (DE) | 2008-05-21 | — | — | EP | claimed |
| US-5463148-A | Process for the preparation of chlorofluoronitrobenzenes | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-31 | — | — | US | claimed |
| EP-0536175-B1 | PROCESS FOR PRODUCING CHLOROFLUORONITRO BENZENES AND DIFLUORONITRO BENZENES | HOECHST AG (DE) | 1995-09-20 | — | — | EP | claimed |
| EP-0635303-A1 | Catalyst for nucleophilic aromatic substitutions | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-01-25 | — | — | EP | claimed |
| EP-0615858-A1 | Transparent recording sheets | XEROX CORPORATION (US) | 1994-09-21 | — | — | EP | claimed |
| EP-0615853-A1 | Recording sheets containing phosphonium compounds | XEROX CORPORATION (US) | 1994-09-21 | — | — | EP | claimed |
| US-5330823-A | Transparent recording sheets | XEROX CORPORATION (US) | 1994-07-19 | — | — | US | claimed |
| EP-0536175-A1 | PROCESS FOR PRODUCING CHLOROFLUORONITRO BENZENES AND DIFLUORONITRO BENZENES. | HOECHST AG (DE) | 1993-04-14 | — | — | EP | claimed |
| EP-0523671-A2 | Process for the preparation of chlorofluoronitrobenzenes | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-01-20 | — | — | EP | claimed |
| WO-1992000270-A1 | PROCESS FOR PRODUCING CHLOROFLUORONITRO BENZENES AND DIFLUORONITRO BENZENES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-09 | — | — | WO | claimed |
| US-4496643-A | PHOSPHONIUM, ARSONIUM, OR STIBONIUM COMPOUND IN BINDER AS TONER AND FLUOROCARBON CARRIER COATED PARTICLES | EASTMAN KODAK COMPANY (US) | 1985-01-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306401-A1 | Method For The Production of 5-Fluoro-1,3-Dialkyl-1H-Pyrazol-4-Carbonyl Fluorides | CYP4X1, DHX35, AOX1 | OPRM1 4295/4885DNM1 793/4885TSHR 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.