SCHEMBL4228166

SCHEMBL4228166

CC(=O)NS(=O)(=O)c1ccc(NC(=O)CCc2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 1.00
ALDH1A1 P00352 5/20 0.71
KMT2A Q03164 4/20 0.70
MEN1 O00255 3/20 0.70
TSHR P16473 1/20 0.67
SCN3A Q9NY46 2/20 0.64
PKM P14618 1/20 0.61
MAPT P10636 1/20 0.61
HTT P42858 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61
HSP90AA1 P07900 1/20 0.60
GAA P10253 1/20 0.59
RAB9A P51151 1/20 0.58
POLB P06746 1/20 0.57
HSD17B10 Q99714 1/20 0.57
HPGD P15428 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4830025 0.82 KMT2A (0.70) L3MBTL1ALDH1A1KMT2AMEN1TSHR
SCHEMBL11887676 0.81 TSHR (1.00) L3MBTL1ALDH1A1KMT2AMEN1TSHR
SCHEMBL10285030 0.79 ALDH1A1 (0.68) L3MBTL1ALDH1A1TSHRMAPTNPSR1
SCHEMBL27323350 0.78 MEN1 (0.64) L3MBTL1ALDH1A1KMT2AMEN1TSHR
Methyl Alcohol SCHEMBL4593446 0.78 MAPT (0.93) L3MBTL1ALDH1A1KMT2AMEN1TSHR
SCHEMBL3061430 0.78 MAPT (1.00) KMT2AMEN1TSHRMAPTHTT
SCHEMBL791784 0.77 L3MBTL1 (0.62) L3MBTL1ALDH1A1TSHRPKMMAPT
SCHEMBL1471759 0.77 MAPT (0.77) L3MBTL1ALDH1A1KMT2AMEN1TSHR
SCHEMBL12522878 0.77 PKM (1.00) L3MBTL1ALDH1A1KMT2AMEN1TSHR
Hydrochloric Acid SCHEMBL27689202 0.76 MAPT (0.96) KMT2AMEN1TSHRMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140163078-A1 Mycobacterial Disease Detection, Treatment, and Drug Discovery THE UAB RESEARCH FOUNDATION (US) 2014-06-12 US claimed
US-20090068197-A1 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2009-03-12 US claimed
EP-1996732-A2 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2008-12-03 EP claimed
WO-2007101274-A2 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2007-09-07 WO claimed
US-20140163078-A1 Mycobacterial Disease Detection, Treatment, and Drug Discovery THE UAB RESEARCH FOUNDATION (US) 2014-06-12 US disclosed
US-20140163078-A1 Mycobacterial Disease Detection, Treatment, and Drug Discovery THE UAB RESEARCH FOUNDATION (US) 2014-06-12 US disclosed
US-20140163078-A1 Mycobacterial Disease Detection, Treatment, and Drug Discovery THE UAB RESEARCH FOUNDATION (US) 2014-06-12 US disclosed
US-20140163078-A1 Mycobacterial Disease Detection, Treatment, and Drug Discovery THE UAB RESEARCH FOUNDATION (US) 2014-06-12 US disclosed
US-8603751-B2 Mycobacterial disease detection, treatment, and drug discovery THE UAB RESEARCH FOUNDATION (US) 2013-12-10 US disclosed
US-8603751-B2 Mycobacterial disease detection, treatment, and drug discovery THE UAB RESEARCH FOUNDATION (US) 2013-12-10 US disclosed
EP-2535426-A2 Mycobacterial disease detection, treatment, and drug discovery THE UAB RESEARCH FOUNDATION (US) 2012-12-19 EP disclosed
US-20090068197-A1 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2009-03-12 US disclosed
US-20090068197-A1 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2009-03-12 US disclosed
US-20090068197-A1 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2009-03-12 US disclosed
EP-1996732-A2 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2008-12-03 EP disclosed
EP-1996732-A2 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2008-12-03 EP disclosed
WO-2007101274-A3 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY UAB RESEARCH FOUNDATION (US) 2007-12-21 WO disclosed
WO-2007101274-A2 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2007-09-07 WO disclosed
WO-2007101274-A2 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2007-09-07 WO disclosed
WO-2007101274-A2 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY THE UAB RESEARCH FOUNDATION (US) 2007-09-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140163078-A1 Mycobacterial Disease Detection, Treatment, and Drug Discovery ANP32B, ANP32A, MRPL21 L3MBTL1 615/4885ALDH1A1 2104/4885KMT2A 4577/4885
US-20090068197-A1 MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY ANP32B, ANP32A, MRPL21 L3MBTL1 615/4885ALDH1A1 2104/4885KMT2A 4577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.