Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13526011 | 0.88 | ALOX15 (0.46) | ALOX15SMN1; SMN2HTTLMNACYP2C9 | |
| SCHEMBL22039175 | 0.86 | PAOX (0.52) | ALOX15SMN1; SMN2HTTLMNACYP2C9 | |
| SCHEMBL19576056 | 0.82 | ALOX15 (0.39) | ALOX15SMN1; SMN2HTTLMNACYP2C9 | |
| SCHEMBL8741722 | 0.80 | GABRR1 (0.32) | GABRR1 | |
| SCHEMBL606535 | 0.80 | CHRNB2 (0.49) | ALOX15SMN1; SMN2HTTLMNACYP2C9 | |
| SCHEMBL606534 | 0.80 | ALOX15 (0.42) | ALOX15SMN1; SMN2HTTLMNACYP2C9 | |
| SCHEMBL104010 | 0.80 | ALOX15 (0.50) | ALOX15SMN1; SMN2HTTLMNACYP2C9 | |
| SCHEMBL7771525 | 0.79 | ALOX15 (0.40) | ALOX15SMN1; SMN2HTTLMNACYP2C9 | |
| Hydrochloric Acid SCHEMBL6837622 | 0.79 | GABRR1 (0.31) | MEN1KMT2AGABRR1 | |
| SCHEMBL13675275 | 0.79 | ALOX15 (0.40) | ALOX15SMN1; SMN2HTTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3109235-A1 | METHOD OF PRODUCING PYRIDONE DERIVATIVES | Shionogi & Co., Ltd (JP) | 2016-12-28 | — | — | EP | disclosed |
| US-9505783-B2 | Method of producing pyrone and pyridone derivatives | SHIONOGI & CO., LTD. (JP) | 2016-11-29 | — | — | US | disclosed |
| EP-2412709-B1 | PROCESS FOR PRODUCING PYRONE AND PYRIDONE DERIVATIVES | SHIONOGI & CO (JP) | 2016-05-18 | — | — | EP | disclosed |
| US-9260453-B2 | Method for producing pyrone and pyridone derivatives | SHIONOGI & CO., LTD. (JP) | 2016-02-16 | — | — | US | disclosed |
| US-20160002211-A1 | METHOD OF PRODUCING PYRONE AND PYRIDONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2016-01-07 | — | — | US | disclosed |
| US-20150031876-A1 | METHOD FOR PRODUCING PYRONE AND PYRIDONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2015-01-29 | — | — | US | disclosed |
| US-8865907-B2 | Method of producing pyrone and pyridone derivatives | SHIONOGI & CO., LTD. (JP) | 2014-10-21 | — | — | US | disclosed |
| US-8575144-B2 | Beta-lactamase inhibitory compounds | SOUTHERN METHODIST UNIVERSITY (US) | 2013-11-05 | — | — | US | disclosed |
| US-20130079318-A1 | BETA-LACTAMASE INHIBITORY COMPOUNDS | SOUTHERN METHODIST UNIVERSITY (US) | 2013-03-28 | — | — | US | disclosed |
| US-8299051-B2 | Beta-lactamase inhibitory compounds | SOUTHERN METHODIST UNIVERSITY (US) | 2012-10-30 | — | — | US | disclosed |
| EP-2412709-A1 | PROCESS FOR PRODUCING PYRONE AND PYRIDONE DERIVATIVES | Shionogi & Co., Ltd. (JP) | 2012-02-01 | — | — | EP | disclosed |
| US-20120022251-A1 | METHOD OF PRODUCING PYRONE AND PYRIDONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2012-01-26 | — | — | US | disclosed |
| US-20100009954-A1 | BETA-LACTAMASE INHIBITORY COMPOUNDS | SOUTHERN METHODIST UNIVERSITY | 2010-01-14 | — | — | US | disclosed |
| US-7638546-B1 | Imidazolyl derivatives | IPSEN PHARMA S.A.S. (FR) | 2009-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031876-A1 | METHOD FOR PRODUCING PYRONE AND PYRIDONE DERIVATIVES | PNPO, PDXK, CYP3A5 | ALOX15 779/4885SMN1; SMN2 4560/4885HTT 2997/4885 |
| US-20120022251-A1 | METHOD OF PRODUCING PYRONE AND PYRIDONE DERIVATIVES | PNPO, PDXK, CYP3A5 | ALOX15 804/4885SMN1; SMN2 4496/4885HTT 3043/4885 |
| US-20160002211-A1 | METHOD OF PRODUCING PYRONE AND PYRIDONE DERIVATIVES | PNPO, PDXK, CYP3A5 | ALOX15 804/4885SMN1; SMN2 4496/4885HTT 3043/4885 |
| US-20130079318-A1 | BETA-LACTAMASE INHIBITORY COMPOUNDS | MGAM, GUSB, LCT | ALOX15 1128/4885SMN1; SMN2 3154/4885HTT 4774/4885 |
| US-20100009954-A1 | BETA-LACTAMASE INHIBITORY COMPOUNDS | MGAM, GUSB, LCT | ALOX15 1128/4885SMN1; SMN2 3154/4885HTT 4774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.