Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | AKT1 | P31749 | 3/20 | 0.34 |
| ▸ | RPS6KA1 | Q15418 | 3/20 | 0.34 |
| ▸ | PRKCA | P17252 | 2/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MYLK | Q15746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640360 | 1.00 | IDO1 (0.41) | IDO1AGXTDPP4AKT1RPS6KA1 | |
| SCHEMBL20665441 | 0.86 | IDO1 (0.39) | IDO1AGXTDPP4PRKCAMEN1 | |
| SCHEMBL5455755 | 0.81 | DPP4 (0.37) | IDO1AGXTDPP4PRKCAMEN1 | |
| SCHEMBL27482180 | 0.81 | DPP4 (0.37) | IDO1AGXTDPP4PRKCAMEN1 | |
| SCHEMBL16047108 | 0.79 | DPP4 (0.38) | DPP4AKT1RPS6KA1PRKCAGRK2 | |
| SCHEMBL16047107 | 0.79 | DPP4 (0.38) | DPP4AKT1RPS6KA1PRKCAGRK2 | |
| SCHEMBL13953463 | 0.77 | ESR1 (0.36) | IDO1AGXTDPP4PRKCAMEN1 | |
| SCHEMBL19303918 | 0.74 | IDO1 (0.46) | IDO1AGXTPRKCAMEN1ALDH1A1 | |
| SCHEMBL706473 | 0.74 | IDO1 (0.64) | IDO1AGXTPRKCAMEN1ALDH1A1 | |
| SCHEMBL1585297 | 0.73 | ADRB2 (0.50) | DPP4AKT1RPS6KA1PRKCAGRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| WO-2008136756-A1 | PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099195-A1 | Therapeutic Compounds 570 | OPRL1, OPRK1, OPRM1 | IDO1 3948/4885AGXT 2585/4885DPP4 1577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.