Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 11/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235252 | 0.89 | CHRM1 (0.42) | CHRM1ADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL4236228 | 0.88 | SIGMAR1 (0.50) | CHRM1ADRA1AADRA1BSIGMAR1DRD2 | |
| SCHEMBL4230418 | 0.84 | CHRM1 (0.51) | CHRM1SIGMAR1 | |
| SCHEMBL4049143 | 0.73 | CHRM1 (0.35) | CHRM1L3MBTL1ADRA1DADRA1AADRA1B | |
| SCHEMBL1554091 | 0.73 | CHRM1 (0.49) | CHRM1ADRA1AADRA1BSIGMAR1DRD2 | |
| SCHEMBL4226945 | 0.73 | CHRM1 (0.45) | CHRM1HRH3L3MBTL1ADRA1AADRA1B | |
| SCHEMBL4236355 | 0.73 | CHRM1 (0.43) | CHRM1ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL4051360 | 0.72 | SIGMAR1 (0.47) | CHRM1HRH3L3MBTL1ADRA1AADRA1B | |
| SCHEMBL4231625 | 0.70 | CHRM1 (0.53) | CHRM1SIGMAR1 | |
| SCHEMBL4049616 | 0.70 | SIGMAR1 (0.49) | CHRM1ADRA1AADRA1BSIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |