Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 6/20 | 0.35 |
| ▸ | HTR2A | P28223 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 6/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049143 | 0.92 | CHRM1 (0.35) | CHRM1DRD2HTR2ADRD3ADRA1D | |
| SCHEMBL4222239 | 0.90 | CHRM1 (0.41) | CHRM1DRD2HTR2ADRD3ADRA1D | |
| SCHEMBL4235252 | 0.84 | CHRM1 (0.42) | CHRM1DRD2HTR2ADRD3ADRA1D | |
| SCHEMBL4051360 | 0.83 | SIGMAR1 (0.47) | CHRM1DRD2HTR2AADRA1AADRA1B | |
| SCHEMBL4049616 | 0.81 | SIGMAR1 (0.49) | CHRM1DRD2HTR2AADRA1AADRA1B | |
| SCHEMBL4231625 | 0.81 | CHRM1 (0.53) | CHRM1 | |
| SCHEMBL4226945 | 0.74 | CHRM1 (0.45) | CHRM1DRD2HTR2ADRD3ADRA1A | |
| SCHEMBL4228778 | 0.73 | CHRM1 (0.43) | CHRM1DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL4221310 | 0.72 | CHRM1 (0.37) | CHRM1DRD2HTR2AADRA1AADRA1B | |
| SCHEMBL4886384 | 0.71 | POLB (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |