Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 6/20 | 0.41 |
| ▸ | BRD4 | O60885 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596693 | 0.78 | CREBBP (0.62) | PARP1MAOAMAOBCREBBPBRD4 | |
| SCHEMBL5544990 | 0.77 | PARP1 (0.58) | PARP1MAOAMAOBSMN1; SMN2CREBBP | |
| SCHEMBL7826166 | 0.75 | ALDH1A1 (0.47) | PARP1ALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL19122972 | 0.74 | PARP1 (0.56) | PARP1MAOAMAOBALDH1A1KDM4E | |
| SCHEMBL13074639 | 0.74 | PARP1 (0.56) | PARP1MAOAMAOBALDH1A1KDM4E | |
| SCHEMBL10264723 | 0.74 | PARP1 (0.55) | PARP1MAOAMAOBCREBBPBRD4 | |
| SCHEMBL6360371 | 0.73 | ALDH1A1 (0.46) | PARP1MAOAMAOBALDH1A1GAA | |
| SCHEMBL18181803 | 0.73 | PARP1 (0.58) | PARP1MAOAMAOBALDH1A1KDM4E | |
| SCHEMBL5544997 | 0.73 | MAOA (0.62) | PARP1MAOAMAOBHTR1A | |
| SCHEMBL18474153 | 0.73 | PARP1 (0.54) | PARP1MAOAMAOBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156575-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | US | disclosed |
| US-20090156575-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | US | disclosed |
| US-20090156575-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | US | disclosed |
| EP-1926730-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | AstraZeneca AB (SE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007030061-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007030061-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2007-03-15 | — | — | WO | disclosed |
| EP-0826684-B1 | PIPERIDINE DERIVATIVES | HISAMITSU PHARMACEUTICAL CO (JP) | 2001-11-21 | — | — | EP | disclosed |
| US-5886011-A | TACHYKININ UNDECAPEPTIDE ANTAGONIST, USEFUL FOR TREATING ASTHMA, OR REMEDY FOR DISEASES ASSOCIATED WITH CENTRAL NERVOUS SYSTEM, DIGESTIVE SYSTEM AND CIRULATORY STYSTEM, AND VARIETY OF PAINS OR INFLAMMATION | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0826684-A1 | PIPERIDINE DERIVATIVES | Hisamitsu Pharmaceutical Co., Inc. (JP) | 1998-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156575-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | CCR8, CCR1, CCR10 | PARP1 1242/4885MAOA 4855/4885MAOB 4671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.