Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.61 |
| ▸ | RAB9A | P51151 | 9/20 | 0.61 |
| ▸ | PLAU | P00749 | 2/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.58 |
| ▸ | PLG | P00747 | 1/20 | 0.58 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.58 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14493609 | 0.84 | PLAU (0.65) | NPC1RAB9APLAUMEN1KMT2A | |
| SCHEMBL28347348 | 0.83 | NPC1 (0.70) | NPC1RAB9APLAUJAK2MEN1 | |
| SCHEMBL3111893 | 0.83 | IMPDH2 (0.72) | NPC1RAB9APLAUJAK2MEN1 | |
| SCHEMBL2229842 | 0.83 | NPC1 (0.76) | NPC1RAB9APLAUMEN1KMT2A | |
| SCHEMBL3503370 | 0.78 | NPC1 (0.84) | NPC1RAB9APLAUMEN1KMT2A | |
| SCHEMBL3899214 | 0.77 | NPC1 (0.56) | NPC1RAB9APLAUJAK2MEN1 | |
| SCHEMBL126415 | 0.76 | PTPN1 (0.87) | NPC1RAB9AJAK2MEN1KMT2A | |
| SCHEMBL14418574 | 0.76 | KDM4E (0.61) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3378320 | 0.76 | RAB9A (0.80) | NPC1RAB9AJAK2SMN1; SMN2MAPT | |
| SCHEMBL3380296 | 0.76 | NPC1 (1.00) | NPC1RAB9AJAK2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077998-A1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008030466-A1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2008-03-13 | — | — | WO | disclosed |
| US-7229753-B2 | Photothermographic material and method for forming images | FUJIFILM CORPORATION (JP) | 2007-06-12 | — | — | US | disclosed |