Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 8/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223205 | 0.96 | TMEM97 (0.39) | UTS2RP2RX3HDAC1S1PR3HDAC3 | |
| SCHEMBL4234963 | 0.91 | KIT (0.40) | UTS2RHDAC1RAB9AHDAC3HDAC2 | |
| SCHEMBL3230263 | 0.91 | MCHR1 (0.41) | UTS2RP2RX3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3234270 | 0.90 | TMEM97 (0.38) | UTS2RP2RX3HDAC1S1PR3HDAC3 | |
| SCHEMBL4228901 | 0.88 | HDAC1 (0.47) | UTS2RHDAC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3234623 | 0.87 | TMEM97 (0.39) | UTS2RHDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL4229101 | 0.87 | ALDH1A1 (0.39) | UTS2RHDAC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3219213 | 0.87 | SMN1; SMN2 (0.38) | UTS2RP2RX3HDAC1SMN1; SMN2S1PR3 | |
| SCHEMBL3232026 | 0.87 | TMEM97 (0.39) | UTS2RHDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL3227819 | 0.87 | TMEM97 (0.41) | HDAC1HDAC3HDAC2NCOR2TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |