SCHEMBL4237341

SCHEMBL4237341

C=C(C(=O)O)c1ccc(C=Cc2ccc(N(c3ccc(C)cc3)c3ccc(C)cc3)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.46
TRPM8 Q7Z2W7 2/20 0.43
ALDH1A1 P00352 3/20 0.43
CYP1B1 Q16678 2/20 0.43
CYP3A4 P08684 1/20 0.43
HPGD P15428 1/20 0.43
MAOB P27338 6/20 0.42
MAOA P21397 4/20 0.42
RAB9A P51151 2/20 0.42
POLB P06746 1/20 0.42
FOS P01100 1/20 0.41
JUN P05412 1/20 0.41
CTDSP1 Q9GZU7 1/20 0.40
HDAC1 Q13547 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KDM4E B2RXH2 1/20 0.39
GAA P10253 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP1A1 P04798 1/20 0.38
AKR1C3 P42330 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4237599 1.00 MAPT (0.46) MAPTTRPM8ALDH1A1CYP1B1CYP3A4
SCHEMBL13918064 0.96 HDAC1 (0.45) MAPTTRPM8ALDH1A1CYP1B1CYP3A4
SCHEMBL13918060 0.89 RARA (0.39) MAPTTRPM8ALDH1A1CYP1B1CYP3A4
SCHEMBL13918062 0.88 HDAC1 (0.45) MAPTTRPM8ALDH1A1CYP1B1RAB9A
SCHEMBL13918058 0.86 ALDH1A1 (0.39) MAPTTRPM8ALDH1A1CYP1B1MAOB
SCHEMBL4237472 0.86 TTR (0.46) MAPTTRPM8ALDH1A1CYP1B1CYP3A4
SCHEMBL4244284 0.86 TTR (0.46) MAPTTRPM8ALDH1A1CYP1B1CYP3A4
SCHEMBL4238188 0.86 HDAC1 (0.47) MAPTTRPM8CYP1B1CYP3A4MAOB
SCHEMBL13918059 0.86 CTDSP1 (0.37) MAPTALDH1A1CYP1B1MAOBMAOA
SCHEMBL2978906 0.86 ALDH1A1 (0.42) MAPTALDH1A1HPGDRAB9AHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7507509-B2 Electrophotographic photoreceptor, and image forming method, image forming apparatus and process cartridge using the electrophotographic photoreceptor RICOH COMPANY, LTD. (JP) 2009-03-24 US disclosed
US-7507509-B2 Electrophotographic photoreceptor, and image forming method, image forming apparatus and process cartridge using the electrophotographic photoreceptor RICOH COMPANY, LTD. (JP) 2009-03-24 US disclosed
US-20060078809-A1 Electrophotographic photoreceptor, and image forming method, image forming apparatus and process cartridge using the electrophotographic photoreceptor RICOH COMPANY, LTD. (JP) 2006-04-13 US disclosed