Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.48 |
| ▸ | RELA | Q04206 | 3/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233688 | 0.94 | MEN1 (0.50) | PLAURAB9AKMT2AGAATRPV4 | |
| SCHEMBL4067193 | 0.92 | VCP (0.57) | PLAURAB9AKMT2AGAAMAPT | |
| SCHEMBL12298170 | 0.92 | MAPT (0.54) | PLAURAB9AKMT2AGAATRPV4 | |
| SCHEMBL4242424 | 0.92 | ALOX5 (0.54) | PLAURAB9AKMT2AGAAMAPT | |
| SCHEMBL4065329 | 0.91 | PKM (0.47) | PLAURAB9AKMT2AGAATRPV4 | |
| SCHEMBL4066150 | 0.90 | PLAU (0.57) | PLAURAB9AKMT2AGAATRPV4 | |
| SCHEMBL4241367 | 0.90 | AMY1A (0.62) | PLAURAB9AKMT2AGAAMAPT | |
| SCHEMBL4057215 | 0.89 | CYP1A2 (0.54) | PLAURAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL4243912 | 0.89 | MEN1 (0.52) | PLAURAB9AKMT2AGAATRPV4 | |
| SCHEMBL4239248 | 0.87 | CFTR (0.56) | PLAURAB9AKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010871-A2 | PYRAZOLE DERIVATIVES AS ANTAGONISTS OF ADENOSINE A3 RECEPTOR | ADDEX PHARMA S.A. (CH) | 2009-01-22 | — | — | WO | disclosed |