SCHEMBL4240532

SCHEMBL4240532

COc1cccc(-c2cncc(C#N)c2Nc2cccc3c2CC(=O)N3)c1OC

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRKCQ Q04759 20/20 0.49
PRKCD Q05655 8/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2987466 0.85 PRKCQ (0.63) PRKCQPRKCD
SCHEMBL4194236 0.80 PRKCQ (0.52) PRKCQPRKCD
SCHEMBL4191870 0.78 SRC (0.58) PRKCQPRKCD
SCHEMBL2986804 0.77 PRKCQ (0.49) PRKCQPRKCD
SCHEMBL4190125 0.74 PRKCQ (0.65) PRKCQPRKCD
SCHEMBL4187943 0.74 PRKCQ (0.66) PRKCQPRKCD
SCHEMBL2974245 0.71 PRKCQ (0.79) PRKCQPRKCD
SCHEMBL4247140 0.70 PRKCQ (0.57) PRKCQPRKCD
SCHEMBL4245343 0.70 PRKCQ (0.42) PRKCQPRKCD
SCHEMBL2267107 0.66 DRD2 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029543-A2 SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS Wyeth (US) 2009-03-04 EP claimed
WO-2007146376-A2 SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS WYETH (US) 2007-12-21 WO claimed