Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 10/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4232855 | 0.88 | KEAP1 (0.39) | KEAP1NFE2L2ALDH1A1L3MBTL1 | |
| SCHEMBL1110442 | 0.87 | RORC (0.45) | KEAP1NFE2L2 | |
| SCHEMBL12116672 | 0.87 | NR1H4 (0.47) | POLBHPGDHTTALDH1A1CA12 | |
| SCHEMBL12115528 | 0.86 | HPGD (0.39) | POLBHPGDHTTTRPM8CA12 | |
| SCHEMBL1110478 | 0.84 | GPR27 (0.47) | HTTKEAP1NFE2L2ALDH1A1MEN1 | |
| SCHEMBL1317802 | 0.84 | KEAP1 (0.43) | KEAP1NFE2L2ALDH1A1L3MBTL1 | |
| SCHEMBL4236968 | 0.82 | KEAP1 (0.40) | KEAP1NFE2L2ALDH1A1L3MBTL1 | |
| SCHEMBL1110353 | 0.82 | OXTR (0.41) | HTTKEAP1NFE2L2ALDH1A1CA12 | |
| SCHEMBL13658806 | 0.82 | KEAP1 (0.46) | KEAP1NFE2L2 | |
| SCHEMBL3299971 | 0.80 | ROCK1 (0.41) | POLBHPGDHTTKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127723-A1 | NEW ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-22 | — | — | WO | disclosed |