Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4244523 | 0.83 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3PSEN1PSEN2 | |
| SCHEMBL4242082 | 0.79 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL4682986 | 0.79 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3NOS2CCR5 | |
| SCHEMBL4240060 | 0.78 | SLC6A2 (0.60) | SLC6A2SLC6A4SLC6A3NOS2CCR5 | |
| SCHEMBL4925756 | 0.76 | HTR2C (0.53) | HTR2CHSD11B1ALDH1A1LMNAMEN1 | |
| SCHEMBL4245108 | 0.74 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3NOS2CCR5 | |
| SCHEMBL4241523 | 0.74 | CCR5 (0.52) | CCR5KCNH2 | |
| SCHEMBL4242202 | 0.73 | CCR5 (0.51) | SLC6A2SLC6A4SLC6A3CCR5KCNH2 | |
| SCHEMBL4309799 | 0.72 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3NOS2 | |
| SCHEMBL312403 | 0.71 | SLC6A2 (0.78) | SLC6A2SLC6A4SLC6A3NOS2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491735-B2 | Chemokine receptor binding compounds | GENZYME CORPORATION (US) | 2009-02-17 | — | — | US | disclosed |
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| US-20050277670-A1 | Chemokine receptor binding compounds | ANORMED INC. | 2005-12-15 | — | — | US | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277670-A1 | Chemokine receptor binding compounds | CCR5, CXCR3, CCL5 | SLC6A2 3198/4885SLC6A4 3084/4885SLC6A3 2527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.