Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 5/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4243414 | 0.80 | PSEN1 (0.37) | BRD4HTR6ACVR1GAAKMT2A | |
| SCHEMBL4235159 | 0.76 | HTR6 (0.34) | BRD4HTR6ACVR1MAPTMEN1 | |
| SCHEMBL4225953 | 0.69 | HTR6 (0.35) | BRD4PPARGPPARDHTR6MEN1 | |
| SCHEMBL4235902 | 0.68 | HTR6 (0.41) | BRD4HTR6PDE4APDE4BPDE4C | |
| SCHEMBL4515229 | 0.68 | MAOA (0.37) | CYP19A1PDE4BMAPTKMT2AKDM4E | |
| SCHEMBL4234116 | 0.67 | HTR6 (0.45) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4233489 | 0.65 | KDM4E (0.48) | BRD4HTR6PDE4APDE4BPDE4C | |
| SCHEMBL4058080 | 0.65 | PDE4A (0.45) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4235468 | 0.65 | HTR6 (0.44) | BRD4HTR6PDE4APDE4BPDE4C | |
| SCHEMBL12359757 | 0.62 | PPARG (0.55) | FABP4PPARGPPARDHTR6PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |