Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KDM5C | P41229 | 1/20 | 0.50 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.50 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20470027 | 0.91 | ALDH1A1 (0.50) | KDM4EKDM5CPHF8KDM2ACTSD | |
| SCHEMBL1934843 | 0.86 | KDM4E (0.54) | KDM4EKDM5CPHF8KDM2ACTSD | |
| SCHEMBL1246629 | 0.83 | KDM4E (0.52) | KDM4EKDM5CPHF8KDM2ACTSD | |
| SCHEMBL3420168 | 0.79 | HDAC1 (0.56) | KDM4EKDM5CPHF8KDM2AHDAC3 | |
| SCHEMBL4525713 | 0.78 | CTSD (0.41) | KDM4EKDM5CPHF8KDM2ACTSD | |
| SCHEMBL28219205 | 0.77 | ALDH1A1 (0.62) | KDM4EKDM5CPHF8KDM2ACTSD | |
| SCHEMBL218953 | 0.77 | KDM4E (0.60) | KDM4EKDM5CPHF8KDM2ACTSD | |
| SCHEMBL49856 | 0.77 | ALDH1A1 (0.62) | KDM4EKDM5CPHF8KDM2ACTSD | |
| SCHEMBL3169675 | 0.76 | ALDH1A1 (0.47) | KDM4EKDM5CPHF8KDM2ACTSD | |
| SCHEMBL320940 | 0.75 | PRMT1 (0.58) | TSHRPRMT1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831075-A1 | 1,3,4-OXADIAZOLE AND 1,3,4-THIADIAZOLE BETA-LACTAMASE INHIBITORS | Cubist Pharmaceuticals, Inc. (US) | 2015-02-04 | — | — | EP | disclosed |
| CN-104334558-A | 1,3, 4-oxadiazole and 1,3, 4-thiadiazole beta-lactamase inhibitors | CUBIST PHARM INC | 2015-02-04 | — | — | CN | disclosed |
| WO-2013149121-A1 | 1,3,4-OXADIAZOLE AND 1,3,4-THIADIAZOLE BETA-LACTAMASE INHIBITORS | CUBIST PHARMACEUTICALS, INC. (US) | 2013-10-03 | — | — | WO | disclosed |
| US-20090215743-A1 | Tricyclic benzazepine derivatives and their use | BAYER HEALTHCARE AG (DE) | 2009-08-27 | — | — | US | disclosed |
| CN-1926143-A | Tricyclic benzazepine * derivatives as squalene synthase inhibitors for the treatment of cardiovascular diseases | BAYER HEALTHCARE AG (DE) | 2007-03-07 | — | — | CN | disclosed |
| EP-1706413-A1 | TRICYCLIC BENZAZEPINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS USED FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005068472-A1 | TRICYCLIC BENZAZEPINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS USED FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215743-A1 | Tricyclic benzazepine derivatives and their use | CACNA1I, HDAC3, AADAC | KDM4E 1712/4885KDM5C 1653/4885PHF8 1581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.