Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17461385 | 0.83 | ADRB1 (0.43) | KDM4EALDH1A1MAPK1TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL28679060 | 0.82 | ALDH1A1 (0.45) | KDM4EALDH1A1MAPK1TSHRHSD17B10 | |
| SCHEMBL1360345 | 0.77 | PIK3CA (0.58) | KDM4EPIK3CAPIK3R1ALDH1A1MAPK1 | |
| SCHEMBL1674211 | 0.76 | JAK2 (0.59) | MAPK1TP53 | |
| SCHEMBL22576043 | 0.75 | TP53 (0.45) | KDM4EPIK3CAPIK3R1ALDH1A1TSHR | |
| SCHEMBL336706 | 0.74 | PIK3CD (0.50) | KDM4EPIK3CAALDH1A1MAPK1TSHR | |
| SCHEMBL30438100 | 0.74 | SYK (0.49) | PIK3CAALDH1A1MTORPIK3CDPIK3CB | |
| SCHEMBL2420211 | 0.73 | HTR3A (0.67) | KDM4EPIK3CAALDH1A1MAPK1MTOR | |
| SCHEMBL29460463 | 0.73 | HTR3A (0.67) | KDM4EPIK3CAALDH1A1MAPK1MTOR | |
| SCHEMBL4767779 | 0.73 | MAPT (0.47) | KDM4EPIK3CAALDH1A1MTORHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | WYETH (US) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | MTOR, PIK3CA, PIK3CD | KDM4E 1572/4885PIK3CA 2/4885PIK3R1 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.