SCHEMBL424441

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL424442	1.00	GRM4 (0.42)	GRM4LRRK2SIGMAR1AKT1KDM4E
	SCHEMBL427799	0.85	MAPT (0.52)	KDM4ELMNAMEN1KMT2AL3MBTL1
	SCHEMBL4400056	0.85	MAPT (0.52)	KDM4ELMNAMEN1KMT2AL3MBTL1
	SCHEMBL429881	0.85	SIGMAR1 (0.39)	SIGMAR1AKT1KDM4ELMNAMEN1
	SCHEMBL427798	0.85	MAPT (0.52)	KDM4ELMNAMEN1KMT2AL3MBTL1
	SCHEMBL429880	0.85	SIGMAR1 (0.39)	SIGMAR1AKT1KDM4ELMNAMEN1
	SCHEMBL429033	0.85	SIGMAR1 (0.40)	GRM4LRRK2SIGMAR1KDM4ELMNA
	SCHEMBL429032	0.85	SIGMAR1 (0.40)	GRM4LRRK2SIGMAR1KDM4ELMNA
	SCHEMBL13759313	0.84	CRHR1 (0.41)	GRM4SIGMAR1MEN1KMT2AMAOB
	SCHEMBL425948	0.84	SIGMAR1 (0.40)	SIGMAR1AKT1KDM4ELMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.