Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.34 |
| ▸ | CTSL | P07711 | 5/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241257 | 0.84 | CTSL (0.37) | CTSKCTSLCTSSCTSBCTSC | |
| SCHEMBL4244407 | 0.78 | ANO1 (0.36) | CTSKCTSLCTSSCTSBANO1 | |
| SCHEMBL4069813 | 0.78 | CTSK (0.34) | CTSKCTSLCTSSCTSBNAMPT | |
| SCHEMBL4247124 | 0.77 | CTSL (0.37) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4240318 | 0.77 | CTSL (0.33) | CTSKCTSLCTSSCTSBCTSC | |
| SCHEMBL4069051 | 0.73 | CTSK (0.35) | CTSKCTSLCTSSCTSBNAMPT | |
| SCHEMBL11889808 | 0.72 | CTSC (0.33) | CTSKCTSLCTSSCTSBCTSC | |
| SCHEMBL4066120 | 0.71 | CTSL (0.37) | CTSKCTSLCTSSCTSBCTSC | |
| SCHEMBL4250621 | 0.71 | CTSS (0.39) | CTSKCTSLCTSSCTSBKDM4E | |
| SCHEMBL4246964 | 0.69 | CTSL (0.37) | CTSKCTSLCTSSCTSBCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| EP-2032535-B1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI SA (FR) | 2012-08-01 | — | — | EP | disclosed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |