Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 14/20 | 0.37 |
| ▸ | CTSS | P25774 | 14/20 | 0.36 |
| ▸ | CTSK | P43235 | 10/20 | 0.36 |
| ▸ | CTSB | P07858 | 9/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241257 | 0.87 | CTSL (0.37) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4239023 | 0.84 | CTSL (0.34) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4245581 | 0.78 | CTSL (0.39) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4240318 | 0.78 | CTSL (0.33) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4245192 | 0.77 | CTSK (0.34) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4244686 | 0.77 | CTSK (0.34) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4244407 | 0.75 | ANO1 (0.36) | CTSLCTSSCTSKCTSB | |
| SCHEMBL11889808 | 0.73 | CTSC (0.33) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4250621 | 0.70 | CTSS (0.39) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4066120 | 0.68 | CTSL (0.37) | CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| EP-2032535-B1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI SA (FR) | 2012-08-01 | — | — | EP | disclosed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |