Sugi Predict

Sugi Predict / Compounds / SCHEMBL424520

SCHEMBL424520

SCHEMBL424520

CCCCCCCCCCOC1CCS(=O)(=O)C1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 2/20 0.51
▸ HTT P42858 2/20 0.51
▸ MAPK1 P28482 1/20 0.51
▸ SMN1; SMN2 Q16637 1/20 0.51
▸ GBA1 P04062 1/20 0.38
▸ LMNA P02545 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ HPGD P15428 1/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ TDP1 Q9NUW8 1/20 0.36
▸ TP53 P04637 1/20 0.36
▸ CYP1A2 P05177 2/20 0.35
▸ POLB P06746 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ EPHX2 P34913 1/20 0.35
▸ CES2 O00748 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11099263 1.00 GAA (0.51) GAAHTTMAPK1SMN1; SMN2GBA1
SCHEMBL4980304 1.00 GAA (0.51) GAAHTTMAPK1SMN1; SMN2GBA1
SCHEMBL11167032 0.93 GAA (0.53) GAAHTTMAPK1SMN1; SMN2LMNA
SCHEMBL11168884 0.85 GAA (0.47) GAAHTTMAPK1SMN1; SMN2LMNA
SCHEMBL1425203 0.82 GAA (0.38) GAAHTTMAPK1SMN1; SMN2L3MBTL1
SCHEMBL11651489 0.79 GAA (0.40) GAAHTTMAPK1SMN1; SMN2CYP1A2
SCHEMBL11106141 0.79 GAA (0.47) GAAHTTMAPK1SMN1; SMN2LMNA
SCHEMBL11522019 0.78 GAA (0.39) GAAHTTMAPK1SMN1; SMN2L3MBTL1
SCHEMBL11651491 0.78 GAA (0.43) GAAHTTMAPK1SMN1; SMN2ALDH1A1
SCHEMBL11169765 0.77 GAA (0.41) GAAHTTMAPK1SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111893770-A Waterproof down jacket and processing technology thereof 温州珍瑾服装有限公司 2020-11-06 — — CN claimed
EP-3356356-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2021-05-26 — — EP disclosed
CN-111893770-A Waterproof down jacket and processing technology thereof 温州珍瑾服装有限公司 2020-11-06 — — CN disclosed
EP-3328973-B1 SEAL SWELL AGENTS FOR LUBRICATING COMPOSITIONS LUBRIZOL CORP (US) 2020-07-01 — — EP disclosed
US-10392371-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2019-08-27 — — US disclosed
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. 2019-06-13 — — US disclosed
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX INC (US) 2018-09-27 — — US disclosed
EP-3356356-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2018-08-08 — — EP disclosed
US-9732071-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2017-08-15 — — US disclosed
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2017-04-06 — — US disclosed
US-7727944-B2 Lubricant compositions containing seal conditioning agents THE LUBRIZOL CORPORATION (US) 2010-06-01 — — US disclosed
US-7727944-B2 Lubricant compositions containing seal conditioning agents THE LUBRIZOL CORPORATION (US) 2010-06-01 — — US disclosed
WO-2010039509-A2 DELIVERY OF SUBSTANTIALLY INSOLUBLE ADDITIVES TO FUNCTIONAL FLUIDS THE LUBRIZOL CORPORATION (US) 2010-04-08 — — WO disclosed
WO-2010014528-A1 FREE STANDING GELS FOR SELF-CONTAINED SLOW RELEASE ADDITIVES THE LUBRIZOL CORPORATION (US) 2010-02-04 — — WO disclosed
EP-2041253-A2 CLEANING COMPOSITION Novozymes Biologicals, Inc. (US) 2009-04-01 — — EP disclosed
US-20080023031-A1 Cleaning Composition NOVOZYMES BIOLOGICALS, INC. (US) 2008-01-31 — — US disclosed
WO-2008005962-A2 CLEANING COMPOSITION NOVOZYMES BIOLOGICALS, INC. (US) 2008-01-10 — — WO disclosed
US-20070298984-A1 Lubricant Compositions Containing Seal Conditioning Agents THE LUBRIZOL CORPORATION (US) 2007-12-27 — — US disclosed
US-20070298984-A1 Lubricant Compositions Containing Seal Conditioning Agents THE LUBRIZOL CORPORATION (US) 2007-12-27 — — US disclosed
WO-2006023317-A1 LUBRICANT COMPOSITIONS CONTAINING SEAL CONDITIONING AGENTS THE LUBRIZOL CORPORATION (US) 2006-03-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10392371-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM4, TRPM6 GAA 3828/4885HTT 3860/4885MAPK1 1501/4885
US-20070298984-A1 Lubricant Compositions Containing Seal Conditioning Agents GPX4, ALOX5, ALOX15 GAA 3284/4885HTT 3243/4885MAPK1 2661/4885
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 GAA 3445/4885HTT 4111/4885MAPK1 1875/4885
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 GAA 3445/4885HTT 4111/4885MAPK1 1875/4885
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 GAA 3445/4885HTT 4111/4885MAPK1 1875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.