Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 7/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL507454 | 0.91 | RORC (0.36) | RORCEPHX2NR1H4WDR5PTGER4 | |
| SCHEMBL10274861 | 0.88 | EPHX2 (0.38) | RORCEPHX2NR1H4WDR5PTGER4 | |
| Succinic Acid SCHEMBL507971 | 0.81 | PPARD (0.38) | EPHX2NR1H4WDR5PTGER4 | |
| Succinic Acid SCHEMBL4247899 | 0.80 | TRPM8 (0.33) | RORCGCGR | |
| SCHEMBL507566 | 0.78 | RORC (0.39) | RORCEPHX2NR1H4ROCK2 | |
| SCHEMBL10476163 | 0.77 | EPHX2 (0.40) | EPHX2NR1H4WDR5PTGER4 | |
| Succinic Acid SCHEMBL508440 | 0.75 | RXFP1 (0.38) | EPHX2PTGER4ROCK2 | |
| Succinic Acid SCHEMBL507048 | 0.73 | CHEK1 (0.35) | — | |
| SCHEMBL10476303 | 0.71 | PPARD (0.41) | EPHX2NR1H4 | |
| Hydrochloric Acid SCHEMBL509191 | 0.71 | PPARD (0.40) | PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099155-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ARRAY BIOPHARMA, INC. | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099155-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | HTR2C, HTR5A, HTR4 | RORC 309/4885EPHX2 1833/4885NR1H4 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.