Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | LIFR | P42702 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632277 | 0.81 | NPC1 (0.34) | SENP7KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL17632072 | 0.74 | NPC1 (0.48) | NPC1RAB9ATSHRNR1H4SMN1; SMN2 | |
| SCHEMBL17632279 | 0.73 | TACR1 (0.43) | KMT2ANR1H4 | |
| SCHEMBL17514018 | 0.72 | KMT2A (0.35) | SENP7CASP3SENP8SENP6KMT2A | |
| SCHEMBL17513876 | 0.71 | GRM5 (0.39) | SENP7CASP3SENP8SENP6NPC1 | |
| SCHEMBL7859593 | 0.63 | TSHR (0.58) | TSHRALDH1A1LMNA | |
| SCHEMBL17513980 | 0.62 | ALDH1A1 (0.38) | KMT2ANPC1RAB9AMAPTTSHR | |
| SCHEMBL28796573 | 0.62 | TSHR (0.56) | TSHRALDH1A1 | |
| SCHEMBL18788868 | 0.62 | TSHR (0.62) | KMT2ANPC1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL2245541 | 0.62 | SMN1; SMN2 (0.41) | SENP7CASP3SENP8SENP6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893569-A4 | SULFONAMIDE COMPOUNDS AND USES THEREOF | ELIXIR PHARMACEUTICALS INC (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1893569-A1 | SULFONAMIDE COMPOUNDS AND USES THEREOF | Elixir Pharmaceuticals, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135860-A1 | SULFONAMIDE COMPOUNDS AND USES THEREOF | ELIXIR PHARMACEUTICALS, INC. (US) | 2006-12-21 | — | — | WO | disclosed |