Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DVL1 | O14640 | 3/20 | 0.52 |
| ▸ | DVL3 | Q92997 | 3/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3078012 | 0.74 | DVL1 (0.60) | DVL1DVL3ADRB2PPARGRARB | |
| SCHEMBL1913466 | 0.73 | DVL1 (0.52) | DVL1DVL3ADRB2PPARGALOX5 | |
| SCHEMBL29381538 | 0.73 | DVL1 (0.52) | DVL1DVL3ADRB2PPARGALOX5 | |
| SCHEMBL6883142 | 0.71 | DVL1 (0.35) | DVL1DVL3ADRB2PPARGRARB | |
| SCHEMBL30282651 | 0.70 | SIRT1 (0.44) | RARBMEN1KMT2A | |
| SCHEMBL28655045 | 0.70 | SIRT1 (0.44) | RARBMEN1KMT2A | |
| SCHEMBL28659051 | 0.69 | SIRT1 (0.43) | RARBMEN1KMT2A | |
| SCHEMBL10260354 | 0.69 | DVL1 (0.64) | DVL1DVL3PDE4DMTNR1AMTNR1B | |
| SCHEMBL28654122 | 0.69 | SIRT1 (0.43) | RARBMEN1KMT2A | |
| SCHEMBL28649772 | 0.68 | SIRT1 (0.44) | RARBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781609-A4 | SMALL MOLECULE INHIBITION OF A PDZ-DOMAIN INTERACTION | UNIV CALIFORNIA (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1781609-A1 | SMALL MOLECULE INHIBITION OF A PDZ-DOMAIN INTERACTION | The Regents of the University of California (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006007542-A1 | SMALL MOLECULE INHIBITION OF A PDZ-DOMAIN INTERACTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-01-19 | — | — | WO | disclosed |