Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7263491 | 1.00 | KDM4E (0.58) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL80718 | 1.00 | KDM4E (0.58) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Bromide SCHEMBL3641371 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL9653571 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Iodide SCHEMBL16961611 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Tetrylammonium SCHEMBL4051701 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Ammonia Solution, Strong SCHEMBL10810468 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL7263493 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Bromide SCHEMBL28903217 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Benzene SCHEMBL27897171 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812368-B1 | METHOD FOR THE PREPARATION OF SEVOFLURANE | PIRAMAL CRITICAL CARE INC (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-2481721-A2 | Product mixtures comprising sevoflurane, sevochlorane and sevochlorane hydrolysis products. | Piramal Critical Care, Inc. (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20120022296-A1 | Method for the preparation of sevoflurane | PIRAMAL CRITICAL CARE, INC. | 2012-01-26 | — | — | US | disclosed |
| US-8058482-B2 | Method for the preparation of sevoflurane | PIRAMAL CRITICAL CARE, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| EP-1812368-A2 | METHOD FOR THE PREPARATION OF SEVOFLURANE | Minrad Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| US-20060205825-A1 | Method for the preparation of sevoflurane | PIRAMAL CRITICAL CARE, INC. | 2006-09-14 | — | — | US | disclosed |
| WO-2006055748-A2 | METHOD FOR THE PREPARATION OF SEVOFLURANE | MINRAD INC. (US) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022296-A1 | Method for the preparation of sevoflurane | HCN3, KCNN3, CYP4F3 | ACHE 1079/4885KDM4E 1404/4885ALDH1A1 3252/4885 |
| US-20060205825-A1 | Method for the preparation of sevoflurane | HCN3, KCNN3, CYP4F3 | ACHE 1079/4885KDM4E 1404/4885ALDH1A1 3252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.