Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 9/20 | 0.56 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23931478 | 0.81 | ALDH1A1 (0.56) | ELANEMAPTALDH1A1GAAKDM4E | |
| SCHEMBL12229940 | 0.76 | NOD2 (0.49) | ELANENOD2NOD1MAPTLMNA | |
| SCHEMBL12571273 | 0.73 | PTGS2 (0.60) | ELANEP2RX4MAPTLMNAHTT | |
| SCHEMBL1999770 | 0.73 | ELANE (0.50) | ELANEMAPTLMNASIRT3ALDH1A1 | |
| SCHEMBL2887731 | 0.71 | MAPT (0.64) | ELANEMAPTHTTALDH1A1GAA | |
| SCHEMBL16110173 | 0.71 | KDM4E (0.58) | ELANELMNAALDH1A1GAAKDM4E | |
| SCHEMBL16796712 | 0.71 | NTRK1 (0.48) | ELANEMAPTALDH1A1GAARECQL | |
| SCHEMBL872109 | 0.71 | P2RX4 (0.81) | ELANEP2RX4MAPTLMNAHTT | |
| Ethyl Benzoate SCHEMBL27940401 | 0.71 | LMNA (0.68) | MAPTLMNAALDH1A1GAA | |
| SCHEMBL13598526 | 0.71 | NOD2 (0.57) | ELANENOD2NOD1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084131-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008055808-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |