Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 8/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4252636 | 0.88 | CHRM1 (0.47) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL4258839 | 0.78 | CHRM1 (0.39) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL2530104 | 0.76 | CHRM1 (0.44) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL2535137 | 0.73 | GRM8 (0.35) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL2532430 | 0.73 | GRM8 (0.35) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL13805071 | 0.73 | CHRM1 (0.49) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL15413070 | 0.72 | KIF11 (0.39) | SMN1; SMN2 | |
| SCHEMBL16627205 | 0.72 | KIF11 (0.39) | SMN1; SMN2 | |
| SCHEMBL4115823 | 0.71 | ALOX15 (0.37) | CYP2C19LMNATSHRGAACYP2D6 | |
| SCHEMBL31615179 | 0.71 | ALOX15 (0.37) | CYP2C19LMNATSHRGAACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149540-A1 | Compositions and Methods for Attenuating Mitochondria-Mediated Cell Injury | UNIVERSITY OF ROCHESTER | 2009-06-11 | — | — | US | disclosed |
| US-20060122267-A1 | Compositions and methods for attenuating mitochondria-mediated cell injury | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149540-A1 | Compositions and Methods for Attenuating Mitochondria-Mediated Cell Injury | SHMT2, TXN2, TXNRD2 | CHRM1 3039/4885CHRM3 2626/4885CHRM2 2926/4885 |
| US-20060122267-A1 | Compositions and methods for attenuating mitochondria-mediated cell injury | SHMT2, TXN2, TXNRD2 | CHRM1 3199/4885CHRM3 2762/4885CHRM2 3065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.