SCHEMBL4252647

SCHEMBL4252647

CC(C)(C)OC(=O)c1cc(=O)c2cc(N)ccc2o1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.49
EGFR P00533 1/20 0.48
SRC P12931 1/20 0.48
MAPT P10636 2/20 0.45
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
GFER P55789 1/20 0.45
GAA P10253 1/20 0.44
ALDH1A1 P00352 1/20 0.43
KDM4E B2RXH2 2/20 0.43
AKR1B1 P15121 2/20 0.42
LCK P06239 1/20 0.41
BCHE P06276 1/20 0.41
ALOX5 P09917 1/20 0.41
ACHE P22303 1/20 0.41
STS P08842 1/20 0.40
POLB P06746 3/20 0.40
USP2 O75604 1/20 0.40
CSNK2A2 P19784 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4250653 0.89 KDM4E (0.52) MAOBSRCMAPTGAAALDH1A1
SCHEMBL4246461 0.84 KDM4E (0.59) MAOBEGFRSRCMAPTNPC1
SCHEMBL29394263 0.83 MAPT (0.63) MAOBMAPTNPC1RAB9ASMN1; SMN2
SCHEMBL4250598 0.82 AKR1B1 (0.63) MAOBEGFRSRCMAPTNPC1
SCHEMBL3487931 0.81 FLT3 (0.61) MAPTNPC1RAB9ASMN1; SMN2GAA
SCHEMBL4252400 0.81 GABRP (0.48) MAOBMAPTNPC1RAB9AGAA
SCHEMBL4253616 0.81 MAOB (0.74) MAOBEGFRSRCMAPTGAA
SCHEMBL4258065 0.78 MAOB (0.72) MAOBEGFRSRCMAPTNPC1
SCHEMBL4253738 0.78 MAOB (0.56) MAOBEGFRSRCMAPTNPC1
SCHEMBL4256569 0.77 ALDH1A1 (0.69) MAOBEGFRSRCMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101497571-B Process for producing chromone compound SUMITOMO CO LTD 2012-07-04 CN disclosed
CN-1911896-B Process for producing benzopyrone compound SUMITOMO CHEMICAL CO 2010-09-15 CN disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
CN-101497571-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2009-08-05 CN disclosed
CN-100509751-C Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2009-07-08 CN disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
CN-1911896-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2007-02-14 CN disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
CN-1649824-A Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2005-08-03 CN disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL MAOB 476/4885EGFR 3027/4885SRC 3793/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL MAOB 476/4885EGFR 3027/4885SRC 3793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.