Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gsk-232802 SCHEMBL3467757 | 0.83 | ESR1 (0.55) | ESR1KDM4EALDH1A1RARBTSHR | |
| SCHEMBL3468408 | 0.82 | ESR1 (0.56) | ESR1PTGS2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL3468569 | 0.80 | ESR1 (0.59) | ESR1LMNAHPGDESR2 | |
| SCHEMBL3075044 | 0.79 | ESR1 (0.50) | ESR1LMNAHPGDHTR2AESR2 | |
| SCHEMBL3468080 | 0.79 | ESR1 (0.51) | ESR1LMNARARBRXRARXRB | |
| SCHEMBL3468554 | 0.79 | ESR1 (0.54) | ESR1CYP3A4CYP2C19LMNAALDH1A1 | |
| SCHEMBL3468126 | 0.77 | CA2 (0.53) | ESR1PTGS1LMNAALDH1A1HPGD | |
| SCHEMBL3467621 | 0.76 | CA1 (0.59) | ESR1CYP2C9CYP3A4CYP2C19LMNA | |
| SCHEMBL3468563 | 0.76 | MMP3 (0.47) | ESR1LMNAALDH1A1ESR2 | |
| SCHEMBL892055 | 0.75 | PTGS2 (0.63) | ESR1PTGS2CYP2C9APPCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569601-B2 | Cycloalkylidene compounds as modulators of estrogen receptor | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-04 | — | — | US | disclosed |
| US-20070213348-A1 | Chemical Compounds | BRITTON JONATHAN E | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213348-A1 | Chemical Compounds | GPER1, ESR2, ESR1 | ESR1 3/4885PTGS2 431/4885CYP2C9 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.