Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | XBP1 | P17861 | 1/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235219 | 0.97 | ALOX5 (0.61) | ALOX5MAPTNPC1TDP1RAB9A | |
| SCHEMBL2706461 | 0.88 | KMT2A (0.66) | MAPTNPC1TDP1RAB9ASMN1; SMN2 | |
| SCHEMBL6002245 | 0.88 | KMT2A (0.70) | MAPTNPC1TDP1RAB9ASMN1; SMN2 | |
| SCHEMBL1777985 | 0.88 | ALOX5 (0.60) | ALOX5MAPTNPC1TDP1RAB9A | |
| SCHEMBL4258805 | 0.87 | MRGPRX4 (0.76) | ALOX5MAPTNPC1SMN1; SMN2MRGPRX4 | |
| SCHEMBL9561783 | 0.86 | TDP1 (0.52) | ALOX5MAPTNPC1TDP1RAB9A | |
| SCHEMBL9343792 | 0.85 | TDP1 (0.58) | MAPTNPC1TDP1RAB9ASMN1; SMN2 | |
| SCHEMBL7947263 | 0.85 | TDP1 (0.51) | MAPTNPC1TDP1RAB9ASMN1; SMN2 | |
| SCHEMBL25462523 | 0.84 | KDM4E (0.58) | MAPTNPC1TDP1RAB9ASMN1; SMN2 | |
| SCHEMBL1779167 | 0.84 | ALOX5 (0.59) | ALOX5MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012061-A1 | A Method of Treating Cancer | MERCK SHARP & DOHME CORP. | 2009-01-08 | — | — | US | disclosed |
| EP-1791969-A4 | A METHOD OF TREATING CANCER | MERCK & CO INC (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1791969-A2 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006031607-A2 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012061-A1 | A Method of Treating Cancer | KIF5B, MKI67, KIF2C | ALOX5 4368/4885MAPT 1211/4885NPC1 1550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.