Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.76 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.69 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.69 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.64 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.60 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5921632 | 0.97 | MRGPRX4 (0.76) | MRGPRX4NR4A2NR4A1NR4A3ALOX5 | |
| Hydrochloric Acid SCHEMBL8380168 | 0.95 | MRGPRX4 (0.74) | MRGPRX4NR4A2NR4A1NR4A3ALOX5 | |
| SCHEMBL18546031 | 0.89 | MRGPRX4 (0.69) | MRGPRX4NR4A2NR4A1NR4A3NPC1 | |
| SCHEMBL4254032 | 0.87 | ALOX5 (0.62) | MRGPRX4NR4A2NR4A1NR4A3ALOX5 | |
| SCHEMBL6342568 | 0.87 | NR4A2 (0.71) | MRGPRX4NR4A2NR4A1NR4A3ALOX5 | |
| SCHEMBL9301215 | 0.87 | MRGPRX4 (1.00) | MRGPRX4NR4A2ALOX5SMN1; SMN2 | |
| SCHEMBL1777985 | 0.86 | ALOX5 (0.60) | MRGPRX4NR4A2NR4A1NR4A3ALOX5 | |
| SCHEMBL27754433 | 0.85 | NR4A2 (0.69) | MRGPRX4NR4A2NR4A1NR4A3ALOX5 | |
| SCHEMBL8984340 | 0.85 | ALOX5 (0.92) | MRGPRX4ALOX5MEN1KMT2ANPC1 | |
| SCHEMBL6652096 | 0.85 | ALOX5 (0.63) | MRGPRX4NR4A2NR4A1NR4A3ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012061-A1 | A Method of Treating Cancer | MERCK SHARP & DOHME CORP. | 2009-01-08 | — | — | US | disclosed |
| EP-1791969-A4 | A METHOD OF TREATING CANCER | MERCK & CO INC (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1791969-A2 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006031607-A2 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 2006-03-23 | — | — | WO | disclosed |
| US-7001900-B2 | Azabicyclic compounds for the treatment of disease | PFIZER INC. (US) | 2006-02-21 | — | — | US | disclosed |
| EP-1478646-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20030236270-A1 | Azabicyclic compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | disclosed |
| WO-2003072578-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012061-A1 | A Method of Treating Cancer | KIF5B, MKI67, KIF2C | MRGPRX4 3358/4885NR4A2 3254/4885NR4A1 3494/4885 |
| US-20030236270-A1 | Azabicyclic compounds for the treatment of disease | MALT1, TPMT, CYP2B6 | MRGPRX4 2918/4885NR4A2 259/4885NR4A1 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.