SCHEMBL4254350

SCHEMBL4254350

Cc1cn(C)c(=O)nc1N

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 3/20 0.34
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
HPGD P15428 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ATAD2 Q6PL18 1/20 0.31
BRPF1 P55201 1/20 0.31
GAA P10253 1/20 0.30
AURKA O14965 1/20 0.30
TTK P33981 1/20 0.30
AURKB Q96GD4 1/20 0.30
INCENP Q9NQS7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21912594 0.80 AURKA (0.34) AURKATTKAURKBINCENP
SCHEMBL17041803 0.80 EP300 (0.33) EP300KDM4EALDH1A1CYP1A2CYP2D6
SCHEMBL24871115 0.78
SCHEMBL12994242 0.78 PI4KA (0.33) EP300ALDH1A1
SCHEMBL2515269 0.77 KDM4E (0.34) KDM4EALDH1A1HPGD
SCHEMBL15456757 0.77 EP300 (0.34) EP300KDM4EALDH1A1
SCHEMBL16869991 0.77 AURKA (0.33) AURKATTKAURKBINCENP
SCHEMBL13586939 0.77
SCHEMBL1225898 0.77 ALB (0.38) EP300
SCHEMBL2194330 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 213 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111836823-B Beta-modified phosphate compound precursor, beta-modified phosphate compound, reaction inhibitor, and pharmaceutical product containing these compounds, and reaction inhibition method 国立研究开发法人科学技术振兴机构 2023-06-30 CN claimed
CN-111836823-A Precursor of beta-modified phosphate compound, reaction inhibitor, pharmaceutical containing these compounds, and method for inhibiting reaction 国立研究开发法人科学技术振兴机构 2020-10-27 CN claimed
WO-2019172394-A1 β-MODIFIED PHOSPHORIC ACID COMPOUND PRECURSOR, β-MODIFIED PHOSPHORIC ACID COMPOUND, REACTION INHIBITOR, AND MEDICINE INCLUDING SAME, AND REACTION INHIBITION METHOD 国立研究開発法人科学技術振興機構 2019-09-12 WO claimed
EP-1895840-A2 P2Y6 RECEPTOR AGONISTS FOR TREATING LUNG DISEASES Inspire Pharmaceuticals, Inc. (US) 2008-03-12 EP claimed
WO-2007002945-A2 P2Y6 RECEPTOR AGONISTS FOR TREATING LUNG DISEASES INSPIRE PHARMACEUTICALS, INC. (US) 2007-01-04 WO claimed
US-12037636-B2 Polynucleotide synthesis method, kit and system OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-07-16 US disclosed
US-12037636-B2 Polynucleotide synthesis method, kit and system OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-07-16 US disclosed
WO-2024137765-A1 TRANSITION-METAL CATALYST COMPOSITIONS AND METHODS FOR SEQUENCING BY SYNTHESIS ILLUMINA, INC. (US) 2024-06-27 WO disclosed
CN-118043333-A Method and apparatus for cutting nucleic acid strand, and method and apparatus for producing double-stranded DNA 国立研究开发法人科学技术振兴机构 2024-05-14 CN disclosed
CN-117858885-A Method and device for purifying nucleotide, and hydrophobic reagent and hydrophobic substrate 国立研究开发法人科学技术振兴机构 2024-04-09 CN disclosed
CN-117295528-A Artificial nucleic acid and nucleic acid delivery method using the same 国立研究开发法人科学技术振兴机构 2023-12-26 CN disclosed
US-20230348524-A1 TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION WAVE LIFE SCIENCES LTD. (SG) 2023-11-02 US disclosed
EP-0586523-A1 DETERMINATION OF PRODRUGS METABOLIZABLE BY THE LIVER AND THERAPEUTIC USE THEREOF YALE UNIVERSITY (US) 1994-03-16 EP disclosed
US-5213972-A Production of thymidine and deoxyuridine, intermediates for AZT CHEMGEN CORPORATION (US) 1993-05-25 US disclosed
EP-0504279-A4 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES 1993-02-17 EP disclosed
WO-1992020816-A1 DETERMINATION OF PRODRUGS METABOLIZABLE BY THE LIVER AND THERAPEUTIC USE THEREOF YALE UNIVERSITY (US) 1992-11-26 WO disclosed
EP-0504279-A1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES. CHEMGEN CORP (US) 1992-09-23 EP disclosed
WO-1991009130-A1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES CHEMGEN CORPORATION (US) 1991-06-27 WO disclosed
US-4232154-A Carbocyclic analogs of cytosine nucleosides exhibiting antiviral and antineoplasticactivity UNITED STATES OF AMERICA (US) 1980-11-04 US disclosed
US-4177348-A VIRICIDES, ANTINEOPLASTIC, ANTILEUKEMIA, ANTICANCER UNITED STATES GOVERNMENT (US) 1979-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230348524-A1 TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION POLRMT, DCLRE1B, RNGTT EP300 4874/4885KDM4E 3297/4885ALDH1A1 3318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.