SCHEMBL1225898

SCHEMBL1225898

Cn1cc(F)c(N)nc1=O

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALB P02768 1/20 0.38
EP300 Q09472 6/20 0.35
DCK P27707 9/20 0.35
BRD4 O60885 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21912594 0.78 AURKA (0.34)
SCHEMBL4254350 0.77 EP300 (0.34) EP300
SCHEMBL28349363 0.77 ALB (0.39) ALBEP300DCK
SCHEMBL15872011 0.77 KDM5B (0.33)
SCHEMBL17041816 0.77 ALB (0.39) ALBEP300DCK
SCHEMBL2852193 0.76 ALB (0.40) ALBEP300DCK
SCHEMBL18080744 0.75 ALB (0.41) ALBEP300DCK
SCHEMBL16869991 0.75 AURKA (0.33)
SCHEMBL2194330 0.75
SCHEMBL13586939 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023183852-A9 PHOSPHONATE PRODRUGS AND USE THEREOF BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) 2023-11-23 WO disclosed
WO-2023178133-A9 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS, INC. (US) 2023-10-26 WO disclosed
WO-2023183852-A1 PHOSPHONATE PRODRUGS AND USE THEREOF BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) 2023-09-28 WO disclosed
WO-2023178133-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS, INC. (US) 2023-09-21 WO disclosed
WO-2022127914-A1 NUCLEOSIDE-THIODIPHOSPHATE-HEPTOSE COMPOUNDS FOR TREATING CONDITIONS ASSOCIATED WITH ALPK1 ACTIVITY PYROTECH (BEIJING) BIOTECHNOLOGY CO., LTD. (CN) 2022-06-23 WO disclosed
WO-2021098379-A1 PHENYLALANINE-AMIDATED NUCLEOTIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 广东中科药物研究有限公司 2021-05-27 WO disclosed
WO-2021034373-A1 CONJUGATES OF GUIDE RNA-CAS PROTEIN COMPLEX ZHONG MINGHONG (US) 2021-02-25 WO disclosed
US-20210054371-A1 Conjugates of Guide RNA-Cas Protein Complex ZHONG MINGHONG (US) 2021-02-25 US disclosed
WO-2020263888-A1 CANNABINOID CONJUGATE MOLECULES DIVERSE BIOTECH, INC. (US) 2020-12-30 WO disclosed
EP-2880033-B1 CYCLIC UREA- OR LACTAM-SUBSTITUTED QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF PURDUE PHARMA LP (US) 2020-06-17 EP disclosed
US-7645747-B2 Improved pharmacokinetic properties, oral bioavailability; side effect reduction GILEAD SCIENCES, INC. (US) 2010-01-12 US disclosed
WO-2009115927-A2 NUCLEOTIDE ANALOGUES WITH QUATERNARY CARBON STEREOGENIC CENTERS AND METHODS OF USE INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) 2009-09-24 WO disclosed
EP-1573019-B1 STEREOSELECTIVE PROCESS FOR THE PRODUCTION OF DIOXOLANE NUCLEOSIDE ANALOGUES SHIRE BIOCHEM INC (CA) 2009-01-14 EP disclosed
US-7442813-B2 Process for producing dioxolane nucleoside analogues SHIRE BIOCHEM INC. (CA) 2008-10-28 US disclosed
US-7442813-B2 Process for producing dioxolane nucleoside analogues SHIRE BIOCHEM INC. (CA) 2008-10-28 US disclosed
WO-2008087558-A2 NUCLEOSIDE AND NUCLEOTIDE ANALOGUES WITH QUATERNARY CARBON CENTERS AND METHODS OF USE INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) 2008-07-24 WO disclosed
US-20070249548-A1 Nucleoside Analog or Salts of the Same GIFU UNIVERSITY (JP) 2007-10-25 US disclosed
US-20070249548-A1 Nucleoside Analog or Salts of the Same GIFU UNIVERSITY (JP) 2007-10-25 US disclosed
US-20070197784-A1 Process for producing dioxolane nucleoside analogues TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-08-23 US disclosed
US-20070197784-A1 Process for producing dioxolane nucleoside analogues TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249548-A1 Nucleoside Analog or Salts of the Same NSUN2, RNMT, RNGTT ALB 3563/4885EP300 4786/4885DCK 56/4885
US-20210054371-A1 Conjugates of Guide RNA-Cas Protein Complex SARNP, SLIRP, NSUN3 ALB 272/4885EP300 3318/4885DCK 727/4885
US-20070197784-A1 Process for producing dioxolane nucleoside analogues NUDT1, DPYD, DUT ALB 3831/4885EP300 4849/4885DCK 34/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.