Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 20/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 11/20 | 0.38 |
| ▸ | CASP7 | P55210 | 7/20 | 0.38 |
| ▸ | CASP6 | P55212 | 6/20 | 0.38 |
| ▸ | CASP9 | P55211 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13608157 | 1.00 | CASP3 (0.39) | CASP3CASP8CASP7CASP6CASP9 | |
| SCHEMBL4251549 | 0.93 | CASP3 (0.39) | CASP3CASP8CASP7CASP6CASP9 | |
| SCHEMBL4253843 | 0.90 | NPBWR1 (0.32) | CASP3CASP8CASP7CASP6CASP9 | |
| SCHEMBL4254234 | 0.89 | CASP3 (0.41) | CASP3CASP8CASP7CASP6CASP9 | |
| SCHEMBL13608160 | 0.89 | CASP3 (0.41) | CASP3CASP8CASP7CASP6CASP9 | |
| SCHEMBL4250398 | 0.89 | CASP3 (0.41) | CASP3CASP8CASP7CASP6CASP9 | |
| SCHEMBL4250465 | 0.87 | CASP3 (0.45) | CASP3CASP8CASP6 | |
| SCHEMBL4250464 | 0.87 | CASP3 (0.45) | CASP3CASP8CASP6 | |
| SCHEMBL4254331 | 0.87 | CASP3 (0.45) | CASP3CASP8CASP6 | |
| SCHEMBL4249823 | 0.86 | CASP3 (0.46) | CASP3CASP8CASP7CASP6CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481537-B2 | Caspase inhibitors based of pyridazinone scaffold | LG LIFE SCIENCES LTD. (KR) | 2013-07-09 | — | — | US | claimed |
| US-20090291959-A1 | CASPASE INHIBITORS BASED OF PYRIDAZINONE SCAFFOLD | LG LIFE SCIENCES LTD. (KR) | 2009-11-26 | — | — | US | claimed |
| US-8481537-B2 | Caspase inhibitors based of pyridazinone scaffold | LG LIFE SCIENCES LTD. (KR) | 2013-07-09 | — | — | US | disclosed |
| US-20090291959-A1 | CASPASE INHIBITORS BASED OF PYRIDAZINONE SCAFFOLD | LG LIFE SCIENCES LTD. (KR) | 2009-11-26 | — | — | US | disclosed |
| EP-2046757-A1 | CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD | LG Life Sciences Ltd. (KR) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008016239-A1 | CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD | LG LIFE SCIENCES LTD. (KR) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291959-A1 | CASPASE INHIBITORS BASED OF PYRIDAZINONE SCAFFOLD | CASP1, CASP2, CASP5 | CASP3 5/4885CASP8 11/4885CASP7 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.