Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 5/20 | 0.44 |
| ▸ | HTR2B | P41595 | 4/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.39 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32665545 | 0.84 | HTR6 (0.49) | HTR6HTR2BGPR119VCPCYP3A4 | |
| SCHEMBL16966426 | 0.82 | CA1 (0.48) | LMNAHTR6HTR2BGPR119VCP | |
| SCHEMBL2301921 | 0.82 | LMNA (0.64) | LMNAMAPK1HTTSMN1; SMN2MAPT | |
| SCHEMBL3454917 | 0.80 | HTR6 (0.65) | LMNAMAPK1HTTSMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL11370762 | 0.79 | HTR6 (0.63) | LMNAMAPK1HTTSMN1; SMN2MAPT | |
| SCHEMBL1704801 | 0.75 | ALDH1A1 (0.62) | LMNAMAPK1HTTSMN1; SMN2MAPT | |
| SCHEMBL3453542 | 0.75 | DRD2 (0.72) | LMNAMAPK1SMN1; SMN2MAPTRECQL | |
| Bromide SCHEMBL9310896 | 0.74 | ALDH1A1 (0.60) | LMNAMAPK1HTTSMN1; SMN2MAPT | |
| SCHEMBL21624833 | 0.73 | NR1H2 (0.54) | GPR119DRD2NR1H2NR1H3 | |
| SCHEMBL21624835 | 0.73 | NR1H2 (0.54) | GPR119DRD2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215818-A1 | THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-27 | — | — | US | disclosed |
| EP-2046333-A2 | THIOZOLIDINEDIONE DERIVATIVES AS P13 KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008014219-A2 | THIOZOLIDINEDIONE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215818-A1 | THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PI4KA, PIP4K2A | LMNA 4882/4885MAPK1 784/4885HTT 1416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.