Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 6/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.41 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.41 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.41 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.41 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.41 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.41 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.41 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13699670 | 0.80 | MCL1 (0.57) | KDM4EALDH1A1HPGDHSD17B10LCK | |
| Ammonia Solution, Strong SCHEMBL4256892 | 0.79 | MAOA (0.41) | KDM4EALDH1A1HPGDHSD17B10MAOA | |
| SCHEMBL4251368 | 0.76 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDHSD17B10MAOA | |
| SCHEMBL28290291 | 0.76 | MAOA (0.50) | MAOAEGFRLCKATP1A1ATP1B1 | |
| SCHEMBL13699673 | 0.75 | HPGD (0.55) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL20534983 | 0.73 | MAPT (0.44) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL13699676 | 0.73 | CYP1A2 (0.44) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL1006030 | 0.72 | MAPT (0.67) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL20534839 | 0.70 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL20535444 | 0.70 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090239860-A1 | NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-09-24 | — | — | US | disclosed |
| EP-1710233-A1 | NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE | Kissei Pharmaceutical Co., Ltd. (JP) | 2006-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239860-A1 | NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE | ADORA2A, ADORA2B, HTR1F | KDM4E 4227/4885ALDH1A1 559/4885HPGD 3251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.